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Semen Quality and Risk Factors for Mortality

Batty, G. Davida; Mortensen, Laust H.b; Shipley, Martin J.a

doi: 10.1097/EDE.0000000000000968
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From the aDepartment of Epidemiology and Public Health, University College London, London, United Kingdom

bStatistics Denmark and Department of Public Health, University of Copenhagen, Denmark.

Replication of findings: Data are available by application to the Centers for Disease Control and Prevention, USA. Analytical syntax is available from the authors upon request.

The authors report no conflicts of interest.

David Batty generated the idea for the present article, and Laust Mortensen built the data set which was analyzed by Martin Shipley. David Batty wrote the first draft of this article on which all other authors commented.

Supplemental digital content is available through direct URL citations in the HTML and PDF versions of this article (www.epidem.com).

Correspondence: David Batty, Department of Epidemiology & Public Health, University College London, 1–19 Torrington Place, London WC1E 6BT, United Kingdom. E-mail: david.batty@ucl.ac.uk.

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To the Editor:

A short series of recent studies have shown that men with lower quality semen—as indexed by concentration, count, motility—have a raised risk of subsequent mortality,1 chronic disease,2 and health service use.3 With data in this area being drawn from fertility clinic samples where potentially important covariates have, with few exceptions,3 typically not been collected, the possibility that the reported semen quality–health relationships are biased by unmeasured confounding remains. While there seems to be a consensus that selected risk factors for mortality—cigarette smoking,4 higher alcohol intake,5 and obesity or overweight6—are correlated with poorer semen quality, there is a paucity of evidence for many other characteristics, particularly biomarkers such as blood pressure, blood glucose and blood cholesterol.

Described in detail elsewhere,7,8 the Vietnam Experience Study was devised as a cohort study to examine the post-theatre health experience of Vietnam war-era male army personnel who had entered the service in the 1960s and 70s. The protocol was approved by the US Office for Technology Assessment, the Department of Health and Human Sciences Advisory Committee, the Agent Orange Working Group Science Panel, and the US Centers for Disease Control. Participants provided written consent.

Data in the present study are cross-sectional. During a telephone survey in 1985, study members reported their health, health behaviors, marital status, and socioeconomic characteristics, largely in response to standard enquiries. In a medical examination the following year, after an overnight fast, participants provided a blood sample from which triglycerides, cholesterol fractions, and serum glucose level were measured. With the participant in a seated position, blood pressure, resting heart rate, and pulmonary function were assessed.

Study members without self-reported vasectomy were asked to abstain from ejaculation for at least 48 hours prior to semen collection and were provided with a plastic receptacle with insulating cups to maintain sample temperature.7 Following masturbation in their hotel rooms without the use of lubricants or condoms, the men noted the number of days since their most recent ejaculation and delivered samples to a processing room within 30 minutes. We used the following 3 markers of semen quality: sperm concentration (millions of sperm per ml of semen), sperm count (millions of sperm in the total ejaculate), and sperm motility (percentage of motile sperm).

A total of 571 men provided a semen sample, and after excluding participants whose samples were not viable owing to spillage, complete results were available on all 3 semen measures for between 448 and 505 of the sample depending on the mortality risk factor. The mean age of this group was 38.9 year (standard deviation [SD] 2.5) and it was predominantly ethnically white (83%). The mean sperm concentration was 105 (SD 83) millions of sperm per ml of semen, the mean sperm count was 272 (SD 262) million in the total ejaculate, and the mean percent motility was 59 (SD 24). For analysis, sperm concentration and sperm count were log transformed and all 3 measures were standardized (Mean 0, SD 1).

In the Table (categorical risk factors) and eTable, http://links.lww.com/EDE/B459 (continuous risk factors), we show the relationships between the standardized values of these 3 markers of semen quality and an array of risk factors for mortality. In general, men with higher levels of mortality risk factors had the least favorable semen quality profile, and relationships at conventional levels of statistical significance were most commonly seen for sperm concentration. As depicted in the Table, lower sperm concentrations were evident in black men and cigarette smokers. All markers of socio-economic status were linked to semen quality such that men with more basic educational attainment, a modest income, and lower occupational prestige had a lower sperm concentration. Of the more novel relationships examined, associations with mortality risk factors were again typically strongest for sperm concentration, followed by sperm count, and sperm motility. Statistical significance was absent, however, for most of these relationships.

TABLE

TABLE

The present study, though hampered by a small sample size, identified selected variables as being candidate confounders and mediators in studies of sperm concentration and disease risk.

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ACKNOWLEDGMENTS

GDB is supported by the UK Medical Research Council (MR/P023444/1) and the US National Institute on Aging (1R56AG052519-01; 1R01AG052519-01A1), and Martin Shipley by the British Heart Foundation.

G. David Batty,a

Laust H. Mortensen,b and

Martin J. Shipleya

From the aDepartment of Epidemiology and Public Health, University College London, London, United Kingdom; and bStatistics Denmark and Department of Public Health, University of Copenhagen, Denmark.

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REFERENCES

1. Jensen TK, Jacobsen R, Christensen K, Nielsen NC, Bostofte E. Good semen quality and life expectancy: a cohort study of 43,277 men. Am J Epidemiol. 2009;170:559–565.
2. Latif T, Kold Jensen T, Mehlsen J, et al. Semen quality as a predictor of subsequent morbidity: a Danish cohort study of 4,712 men with long-term follow-up. Am J Epidemiol. 2017;186:910–917.
3. Latif T, Lindahl-Jacobsen R, Mehlsen J, et al. Semen quality associated with subsequent hospitalizations - can the effect be explained by socio-economic status and lifestyle factors? Andrology. 2018;6:428–435.
4. Sharma R, Harlev A, Agarwal A, Esteves SC. Cigarette smoking and semen quality: a new meta-analysis examining the effect of the 2010 world health organization laboratory methods for the examination of human semen. Eur Urol. 2016;70:635–645.
5. Ricci E, Al Beitawi S, Cipriani S, et al. Semen quality and alcohol intake: a systematic review and meta-analysis. Reprod Biomed Online. 2017;34:38–47.
6. Sermondade N, Faure C, Fezeu L, et al. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update. 2013;19:221–231.
7. The Centers for Disease Control Vietnam Experience Study. Health status of Vietnam veterans. II. Physical Health. JAMA 1988;259(18):2708–2714.
8. Batty GD, Shipley MJ, Mortensen LH, et al. IQ in late adolescence/early adulthood, risk factors in middle age and later all-cause mortality in men: the Vietnam experience study. J Epidemiol Community Health. 2008;62:522–531.

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