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Re: Thyroid Cancer Among Young People in Fukushima

Takahashi, Hideto; Ohira, Tetsuya; Yasumura, Seiji; Nollet, Kenneth E.; Ohtsuru, Akira; Tanigawa, Koichi; Abe, Masafumi; Ohto, Hitoshi

doi: 10.1097/EDE.0000000000000467
Letters

Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan, htaka@fmu.ac.jp

The authors report no conflicts of interest.

Co-author Kenneth E. Nollet has, in the past 36 months, received travel support from the American Red Cross, the Radiation Injury Treatment Network, the International Atomic Energy Agency, the OECD Nuclear Energy Agency, and the Mayo Clinic Alumni Association for the purpose of reporting personal experience and data from the Fukushima Health Management Survey to groups in Washington, DC; Vienna, Austria; Singapore; Tokyo, Japan; and Phoenix, Arizona.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.

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To the Editor:

Dr. Tsuda and colleagues1 analyzed statistical reports of the Fukushima Health Management Survey published by the Fukushima prefectural government, and obtained markedly higher incidence rates of thyroid cancer in Fukushima Prefecture compared with the rate for all of Japan. Regrettably, their analysis has a serious methodological error regarding the prevalence pool with the 4-year duration.1

They assumed a steady prevalence pool2 of thyroid cancer cases detected by screening in Fukushima with using the definition of the “latent duration,” which is the time period from the date when a case of thyroid cancer became detectable by screening and cytology (“detectable by screening” hereafter) to the date when the thyroid cancer could be diagnosed in a clinical setting without screening or the date of operation (“detectable clinically”), using the duration of 4 years as the maximum length between the nuclear accident and the cancer detection.

This assumption implies that the cancer in all cases became detectable by screening at or after the nuclear accident, and that all of these cancers progressed enough to be detected clinically within 4 years. However, both of them are unreasonable. They ignored two important possibilities: (1) the date at which a patient’s cancer becomes detectable by screening (which is usually unknown) might have preceded the nuclear accident, and (2) the slow growing nature of thyroid cancer3 might cause many slowly progressing cases to remain in the pool. That is, the equilibrium of the pool within 4 years does not hold anymore. Thus, their incidence rate of the clinically detected cancer in Fukushima as the numerator of the paper’s incidence rate ratio—which is the essential index in the paper—is severely overestimated.

The Fukushima Health Management Survey was commissioned by Fukushima Prefecture and has been conducted by the Radiation Medical Science Center for the Fukushima Health Management Survey at Fukushima Medical University since June 2011. With the efforts of over one hundred of the Center’s personnel, the results of the survey have become freely available on our website (http://fmu-global.jp) to ensure attention and transparency and to enable further examination of these findings.

As Professor Scott Davis noted regarding the screening for thyroid cancer after the Fukushima accident,4 “it should be of no surprise that a number of study designs and approaches have been tried, largely driven by the data available.” For the analyses, special attention should always be placed on the inherent limitations of the study.

Hideto Takahashi

Tetsuya Ohira

Seiji Yasumura

Kenneth E. Nollet

Akira Ohtsuru

Koichi Tanigawa

Masafumi Abe

Hitoshi Ohto

Radiation Medical Science Center for the Fukushima Health Management Survey

Fukushima Medical University

Fukushima, Japan

htaka@fmu.ac.jp

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REFERENCES

1. Tsuda T, Tokinobu A, Yamamoto E, Suzuki E.. Thyroid cancer detection by ultrasound among residents ages 18 years and younger in Fukushima, Japan: 2011 to 2014 Epidemiology. 2016;27:316–322
2. Rothman KJ, Greenland S, Lash TL.. Measures of effect and measures of association. Modern Epidemiology. 2012 Philadelphia, PA Lippincott, Williams & Wilkins
3. Williams D.. Thyroid growth and cancer. Eur Thyroid J. 2015;4:164–173
4. Davis S.. Screening for thyroid cancer after the Fukushima disaster. What do we learn from such an effort? Epidemiology. 2016;27:323–325
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