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Periodicity and Trends in the Incidence of Congenital Malformations With Regard to Conception Date of Live and Stillbirths Among Jews and Muslims in Israel, 2000–2006

Agay-Shay, Keren1; Friger, Michael2; Linn, Shai1; Peled, Ammatzia1; Amitai, Yona3; Peretz, Chava4

doi: 10.1097/01.ede.0000392049.38311.57
Abstracts: ISEE 22nd Annual Conference, Seoul, Korea, 28 August–1 September 2010: Reproductive Health and Environment

1University of Haifa, Haifa, Israel; 2Ben-Gurion University, Beer-Sheva, Israel; 3Ministry of Health, Jerusalem, Israel; and 4Tel-Aviv University, Tel-Aviv, Israel.

Abstracts published in Epidemiology have been reviewed by the societies at whose meetings the abstracts have been accepted for presentation. These abstracts have not undergone review by the Editorial Board of Epidemiology.


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Congenital malformations (CM) of male reproductive system, chromosomal aberrations, and secondary sex ratio (SSR) were found to be associated with environmental Endocrine Disruptor Chemicals exposure. The Israeli population is multicultural, consisted of 80% Jews and 18% Muslims. Temporal patterns in birth occurrence and CM incidence rate (IR) were found to differ between them. Therefore, we aimed to investigate and compare trends and periodicity in IR of CM and SSR conceptions of Jews and Muslims in Israel.

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Time-series design based on weekly IR of CM (live and stillbirths) and SSR during 2000–2006. The following CM were considered: male reproductive system—Hypospadias and Cryptorchidism separately and together as part of testicular dysgenesis syndrome (TDS); chromosomal aberrations 21,18,13 trisomies, “other chromosomal” CM, and all chromosomal CM. Data Source—Ministry of Health. Poisson (Trend-Harmonic) models were applied for CM IR to study trends and periodicity of season, half-year, year, and 2-years; a Binomial model was used for SSR.

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TRENDS: In Jews, we found significant nonlinear inclining trends for Cryptorchidism, TDS, and all chromosomal CM. In Muslims, we found significant declining trends for TDS and “other chromosomal” CM group. Trends did not differ significantly between the 2 populations. PERIODICITY: In Jews, we found periodicity for Hypospadias, TDS, 18 trisomy, “other chromosomal” CM, and all chromosomal CM. For Muslim, we found periodicity for Hypospadias, TDS, and all chromosomal CM. Comparison between the 2 populations demonstrated significant differences in the 2-year cycle for male CM and “other chromosomal” CM; and in cycles of season and year for all chromosomal CM. For SSR neither trend nor periodicity was significant in both populations.

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CM with the same periodicity, found in both populations, may be related to common environmental exposures; further investigation is needed to evaluate a causative relationships.

© 2011 Lippincott Williams & Wilkins, Inc.