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Current Fetal Exposure Level of Endocrine Disruptors, Heavy Metals and Brominated Flame Retardants in Japan

Mori, Chisato1,2,3; Matsuno, Yoshiharu1,2,3; Nakaoka, Hiroko1,2; Hanazato, Masamichi1,2; Todaka, Emiko1,2,3

doi: 10.1097/01.ede.0000391912.01081.5a
Abstracts: ISEE 22nd Annual Conference, Seoul, Korea, 28 August–1 September 2010: Chemicals and Environmental Health Issues: Bisphenol A and Flame Retardants
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1Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chiba City, Japan; 2Center for Preventive Medical Science, Chiba University, Chiba City, Japan; and 3Center for Environment, Health and Field Sciences, Chiba University, Kashiwa City, Japan.

Abstracts published in Epidemiology have been reviewed by the societies at whose meetings the abstracts have been accepted for presentation. These abstracts have not undergone review by the Editorial Board of Epidemiology.

O-30A4-6

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Background/Aims:

The current fetal exposure level of endocrine disruptors, heavy metals, and brominated flame retardants (BFRs), and the correlation among them in Japan will be introduced.

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Methods:

More than 300 umbilical cords were collected in Chiba City and concentration levels of endocrine disruptors (polychlorinated biphenyls [PCBs], p,p′-DDTs, p,p′-DDEs, trans-nonachlor, oxychlordane, hexachlorobenzene [HCB], mirex, β-hexachlorocyclohexane [HCH]), heavy metals (Pb, Hg, Cd) and BFRs (polybrominated diphenyl ethers [PBDEs]) in the cord tissue were measured.

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Results:

The average concentrations of total PCBs, p,p′-DDTs, p,p′-DDEs, trans-nonachlor, oxychlordane, HCB, mirex, and β-HCH in umbilical cords were found to be 74.8, 4.3, 128.2, 17.9, 9.1, 23.2, 1.1, and 74.4, respectively (all the data are shown in pg/g wet). The average concentrations of Pb and Hg were found to be 7.8 and 26. The concentration of Cd was lower than the detection level. The concentration of total PBDEs was found to be 25. BDE-47 and BDE-209 were the dominant compounds, the average concentration of BDE-47 and BDE-209 were 7.3 and 7.0, respectively. Among the 27 PBDE congeners, the following 12 were lower than the detection level in all samples: BDE-3, 7, 71, 77, 119, 126, 138, 156, 184, 191, 196, and 206.

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Conclusion:

Significant correlation among each concentration level of endocrine disruptors were found. However, the correlation between endocrine disruptors and heavy metals was not found. Our results indicate that Japanese fetuses are exposed to endocrine disruptors, heavy metals, and BFRs.

© 2011 Lippincott Williams & Wilkins, Inc.