Abstracts: ISEE 22nd Annual Conference, Seoul, Korea, 28 August–1 September 2010: Chemicals and Environmental Health Issues: Bisphenol A and Flame Retardants
The current fetal exposure level of endocrine disruptors, heavy metals, and brominated flame retardants (BFRs), and the correlation among them in Japan will be introduced.
More than 300 umbilical cords were collected in Chiba City and concentration levels of endocrine disruptors (polychlorinated biphenyls [PCBs], p,p′-DDTs, p,p′-DDEs, trans-nonachlor, oxychlordane, hexachlorobenzene [HCB], mirex, β-hexachlorocyclohexane [HCH]), heavy metals (Pb, Hg, Cd) and BFRs (polybrominated diphenyl ethers [PBDEs]) in the cord tissue were measured.
The average concentrations of total PCBs, p,p′-DDTs, p,p′-DDEs, trans-nonachlor, oxychlordane, HCB, mirex, and β-HCH in umbilical cords were found to be 74.8, 4.3, 128.2, 17.9, 9.1, 23.2, 1.1, and 74.4, respectively (all the data are shown in pg/g wet). The average concentrations of Pb and Hg were found to be 7.8 and 26. The concentration of Cd was lower than the detection level. The concentration of total PBDEs was found to be 25. BDE-47 and BDE-209 were the dominant compounds, the average concentration of BDE-47 and BDE-209 were 7.3 and 7.0, respectively. Among the 27 PBDE congeners, the following 12 were lower than the detection level in all samples: BDE-3, 7, 71, 77, 119, 126, 138, 156, 184, 191, 196, and 206.
Significant correlation among each concentration level of endocrine disruptors were found. However, the correlation between endocrine disruptors and heavy metals was not found. Our results indicate that Japanese fetuses are exposed to endocrine disruptors, heavy metals, and BFRs.