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Pre-Diagnostic Serum Concentrations of Organochlorine Compounds and Risk of Testicular Germ Cell Tumors

Purdue, Mark*; Engel, Lawrence; Langseth, Hilde; Needham, Larry§; Andersen, Aage; Barr, Dana§; Blair, Aaron*; Rothman, Nathaniel*; McGlynn, Katherine*

doi: 10.1097/01.ede.0000362813.51687.44
Abstracts: ISEE 21st Annual Conference, Dublin, Ireland, August 25–29, 2009: Symposium Abstracts: Symposia Presentations

*National Cancer Institute, Bethesda, MD, United States; †Memorial Sloan-Kettering Cancer Center, New York, NY, United States; ‡The Norwegian Cancer Registry, Oslo, Norway; and §Centers for Disease Control and Prevention, Atlanta, GA, United States.

Abstracts published in Epidemiology have been reviewed by the organizations of Epidemiology. Affliate Societies at whose meetings the abstracts have been accepted for presentation. These abstracts have not undergone review by the Editorial Board of Epidemiology.


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Background and Objective:

Recent findings suggest that exposure to organochlorine (OC) compounds, chlordanes and p,p'-dichlorodiphenyl- dichloroethylene (p,p'-DDE) in particular, may increase the risk of developing testicular germ cell tumors (TGCT). To further investigate this question, we conducted a nested case-control study of TGCT within the Norwegian Janus serum bank cohort.

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The study was conducted among individuals with serum collected between 1972 and 1978. TGCT cases diagnosed through 1999 (N = 49) were identified through linkage to the Norwegian Cancer Registry. Controls (N = 51) were matched to cases on region, blood draw year and age at blood draw. Measurements of 11 OC insecticide compounds and 34 polychlorinated biphenyl (PCB) congeners were performed using gas chromatography/high-resolution mass spectrometry. Case-control comparisons of lipid-adjusted analyte concentrations were performed using the Wilcoxon signed-rank test. Odds ratios (OR) and 95% confidence intervals (CI) for tertiles of analyte concentration were calculated using conditional logistic regression.

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TGCT cases had elevated concentrations of p,p'-DDE (tertile 3 vs. tertile 1 OR (ORT3) 2.2, 95% CI 0.7–6.5; PWilcoxon = 0.07), oxychlordane (ORT3 3.2, 95% CI 0.6–16.8; PWilcoxon = 0.06), trans-nonachlor (ORT3 2.6, 95% CI 0.7–8.9; PWilcoxon = 0.07) and total chlordanes (ORT3 2.3, 95% CI 0.6–8.6; PWilcoxon = 0.046) compared to controls, although no ORs were statistically significant. Seminoma cases had significantly lower concentrations of PCB congeners #44, #49 and #52 and significantly higher concentrations of congeners #99, #138, #153, #167, #183 and #195.

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Our study provides additional evidence supporting an association between exposures to p,p'-DDE and chlordane compounds, and possibly some PCB congeners, and TGCT risk.

© 2009 Lippincott Williams & Wilkins, Inc.