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Kinetics of PCBs and Other Selected Organochlorines in Eastern Slovak Children from Birth Until 45 Months of Age

Trnovec, Tomas*; Sovcikova, Eva*; Drobna, Beata*; Kocan, Anton*; Lancz, Kinga*; Wimmerova, Sona*; Palkovicova, Lubica*; Hertz-Picciotto, Irva

doi: 10.1097/01.ede.0000362535.81635.58
Abstracts: ISEE 21st Annual Conference, Dublin, Ireland, August 25–29, 2009: Symposium Abstracts

*Slovak Medical University, Bratislava, Slovakia; and †University of California, Davis, Davis, United States.


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Background and Objective:

Polychlorinated biphenyls (PCBs) are ubiquitous persistent pollutants whose role in developmental toxicity is of concern. Their kinetics in infants has not been thoroughly described yet.

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A cohort study (1134 mother-infant pairs) was initiated in 2002, whereby organochlorines were measured in maternal and cord serum samples and in children at 6, 16, and 45-months using high resolution gas chromatography. The present analysis is based on a subgroup of 480 subjects living in Michalovce area.

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In mother serum the CB-153 concentration was 2.34 ± 1.92 (mean ± SD) and 1.70 (median) ng/ml and 224.2 ± 175.4 (mean ± SD) and 175.4 (median) ng/g lipids. In decreasing order, congeners CB 153, 180, 138+163 and 170 were the major contributors to total PCB concentrations in serum. The highest sum of PCB serum concentration was at 6 months reflecting uptake through breast feeding. PCB sum levels decreased between the 6th and 16th month by 16% and from the 16th to 45th month by 9.7%. The most abundant pesticide in serum was pp-DDE, which peaked at 16 months of age. The cord and mother blood concentrations of all analytes correlated well except β-HCH. The ratios of cord:mother for means of analytes were higher than medians, except for pp-DDT, and they were <1 for sum of PCB congeners, CB 153, 138+163, DDE and HCB, indicating concentration equilibrium between lipids in mother and cord plasma. For less abundant congeners, DDT and β-HCH ratios were <1. The 6-month infant:cord ratios reflect uptake of organochlorines by breast feeding.

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These unique longitudinal data are being used for exposure metrics (AUC, MRT) in association with various health outcomes. Further observation of the cohort is planned.

© 2009 Lippincott Williams & Wilkins, Inc.