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Abstracts: ISEE 20th Annual Conference, Pasadena, California, October 12–16, 2008: Symposium Abstracts

A Genome Wide Search for Genetic Variants that Modify Air Pollution Effects on Respiratory Health

Gauderman, W J

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doi: 10.1097/01.ede.0000339705.85321.1b
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Recent CHS investigations have identified associations of childhood asthma and lung function development with regional air pollution, proximity to traffic, and tobacco smoke exposure. The CHS has also shown that genetic variation in specific candidate genes from oxidative stress and inflammatory pathways modify these pollutant effects. To further explore the genetic basis for these respiratory outcomes, we have conducted a genomewide association study (GWAS). Specifically, we have genotyped over 500,000 single-nucleotide polymorphisms (SNPs) on approximately 3,000 CHS study participants. We will describe the results to date of our search for novel genetic loci that contribute directly to asthma risk or lung function development, and for loci that modify the effects of air pollutants on these traits.

© 2008 Lippincott Williams & Wilkins, Inc.