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POLYMORPHISMS IN GSTT1 AND GSTM1, ARSENIC EXPOSURE, AND SKIN LESIONS IN PABNA, BANGLADESH

McCarty, Kathleen*; Quamruzzaman, Quazi; Rahman, Mahmuder; Mahiuddin, Golam; Christiani, David; Houseman, Andres; Zhou, Wei; Wong, Mike; Su, Li

The Sixteenth Conference of the International Society for Environmental Epidemiology (ISEE): Abstracts

*Harvard School of Public Health; †Dhaka Community Hospital; †Dhaka Community Hospital; †Dhaka Community Hospital; ‡Harvard School of Public Health; ‡Harvard School of Public Health; ‡Harvard School of Public Health; ‡Harvard School of Public Health; ‡Harvard School of Public Health

Supported by NIH Research Grants ES 05947, ES 11622, Ms McCarty is supported by training grant T32ES 06790 from NIEHS. The authors wish the thank the Dhaka Community Hospital field team, and the Harvard School of Public Health Molecular Epidemiology Laboratory research team for their collaborative efforts on this project.

ISEE-252

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Introduction:

The study objective was to determine whether polymorphisms in GSTM1, and GSTT1 modify the association between exposure to arsenic through drinking water and the development of skin lesions such as hyperkeratosis and melanosis. To investigate whether metabolic polymorphisms in GSTM1, and GSTT1 and modify toenail arsenic level concentrations.

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Methods:

1200 subjects stratified on gender and age were recruited in a case control study in Pabna, Bangladesh. Subjects were collected 1:1 ratio of cases and controls. Questionnaire data, a water sample and toenail samples were collected on all subjects. Water samples were analyzed by ICP-MS EPA method 200.8. Toenail arsenic concentration was determined by ICP-MS.

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Results:

Non-null GSTT1 was protective in modifying the risk of developing skin lesions given arsenic exposure (p=0.01). Toenail and water samples were highly correlated. Toenail arsenic levels were not modified by polymorphisms in GSTM1 or GSTT1. GSTM1 polymorphisms do not significantly modify the risk between arsenic exposure and skin lesions.

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Discussion:

Polymorphisms in GSTT1 may influence the risk of arsenic-induced skin lesions.

© 2004 Lippincott Williams & Wilkins, Inc.