ENVIRONMENTAL IODINE DEFICIENCY IN URBAN AREAS AND GOITER PREVENTIVE ASPECTS AMONG CHILDREN : Epidemiology

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The Sixteenth Conference of the International Society for Environmental Epidemiology (ISEE): Abstracts

ENVIRONMENTAL IODINE DEFICIENCY IN URBAN AREAS AND GOITER PREVENTIVE ASPECTS AMONG CHILDREN

Ninashvili, Nanuli*; Sekhniashvili, Zurabi; Sekhniashvili, Nino

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ISEE-282

Introduction:

Goiter- the endemic disease of the high mountain regions has recently become a common disease for the whole country, including the urban areas. The high prevalence of goiter among children at the age of 6-12 stressed the need to evaluate the effectiveness of goiter preventive measures in relation with the level of endemicity of the areas and preventive means, applied.

Methods:

Epidemiological and ecological studies were carried out. Two urban areas were selected from the moderate endemic zones of goiter. Effectiveness of preventive measures were assessed by clinical–physical examination of children, evaluation of their intellectual ability by Ravenee Test (adapted to the study) and measurement of T4 and TSH hormones in biosubstrat (blood) by standard methodology (ELISA), using Swiss test-system” General Biological Corp”.

Iodine salt and iodine oil capsules were used for goiter prevention purposes. Study groups were selected from children at the age of 11 because of the highest prevalence rate of goiter among them. The study groups were given iodine oil capsules while the controls were left on sequalae iodine salt preventive regimen. The study and control groups were examined at the beginning of the study and were followed up during one year with quarterly check ups and appropriate screening tests.

Results:

Iodine content in soil in the study areas ranged between 0.5 mg/kg - 0.79 mg/kg. The Ravenee Test results in study groups were within 9.8-10.74 before the study and within 11.0+13.09 after the study, T4 increased from 6.4+1.8 n/mol/l to 9.1+1.4 n/mol/l and TSH decreased from 5.9+1.9 μIU/ml to 3.7+07 μIU/ml. The Ravenee Test results among controls did not exceed 10.74. T4 level was within 7.4+1.8 n/mol/l and TSH – 4.9+1.9 μIU.

Conclusion:

Goiter prevention with iodine oil capsules is significantly effective than prevention with iodine salt in urban moderate endemic areas of goiter in terms of improving children's clinical-physical characteristics and intellectual ability.

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