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An Improvement in Estimation of the Standard Error for the Natural Direct Effect in Causal Mediation Analysis

Gao, Xin, M.S.1; Luo, Li, Ph.D.2

doi: 10.1097/EDE.0000000000001005
Research Letter: PDF Only

1 Department of Mathematics and Statistics, College of Arts and Sciences, University of New Mexico, Albuquerque, NM, USA

2 Division of Epidemiology, Biostatistics and Preventive Medicine, Department of Internal Medicine and UNM Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, USA

Disclosure of Potential Conflicts of Interest: No potential conflicts of interest were disclosed.

Financial support: This work was supported in part by the National Cancer Institute (P30CA118100 to L.L.).

The data and computing code required to replicate the results reported in this work will be available upon request.

ACKNOWLEDGMENTS: X.G. is grateful to Prof. Ronald Christensen for his inspiration on minimum variance unbiased estimator. X.G. also gives special thanks to James Duncan and Victoria J. Gao for their encouragement when he was frustrated.

*Corresponding Author: Li Luo, Ph.D., Assistant Professor, MSC10-5550, 1 University of New Mexico, Albuquerque, New Mexico 87131, Tel: (505)-272-8704, Email:

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