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Exposure to Air Pollution from Traffic and Childhood Asthma Until 12 Years of Age

Gruzieva, Olenaa,b; Bergström, Annaa; Hulchiy, Olesyac; Kull, Ingera,d,e; Lind, Tomasa,e; Melén, Erika,f; Moskalenko, Vitaliyb; Pershagen, Görana,e; Bellander, Toma,e


In the legends for Figures 2 and 3, the symbols are specified incorrectly. Empty (white) circles indicate wheeze ≥ 1 episode; gray circles indicate wheeze ≥ 3 episodes; and filled (black) circles indicate asthma.

Epidemiology. 24(2):339, March 2013.

doi: 10.1097/EDE.0b013e318276c1ea
Air Pollution

Background: There are limited prospective data on long-term exposure to air pollution and effects on childhood respiratory morbidity. We investigated the development of asthma and related symptoms longitudinally over the first 12 years of life in relation to air pollution from road traffic.

Methods: The Swedish birth cohort BAMSE (Children, Allergy, Milieu, Stockholm, Epidemiological Survey) includes 4089 children who were followed up with repeated questionnaires and blood samples for up to 12 years of age. Residential, daycare, and school addresses, time-activity patterns, emission databases, and dispersion models were used to estimate individual exposure to particulate matter with aerodynamic diameter <10 μm (PM10) and nitrogen oxides (NOx) from traffic.

Results: Overall, the data suggested possible associations between exposure to air pollution during the first year of life and asthma and wheezing in children up to 12 years of age. Asthma risks seemed to be particularly increased in children age 8 to 12 years; the overall odds ratio was 2.0 (95% confidence interval = 1.1–3.5), and for nonallergic asthma, the odds ratio was 3.8 (0.9–16.2) for a 5th to 95th percentile increase in time-weighted average exposure to PM10 (corresponding to 7.2 µg/m3). Results were similar using exposure to traffic-NOx.

Conclusions: We found modest positive associations between air pollution exposure from traffic during infancy and asthma in children during the first 12 years of life, with stronger effects suggested for nonallergic asthma.

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From the aInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; bDepartment of Social Medicine and Health Care and cDepartment of Social Hygiene and Organization of Health Protection for Advance Training of Managers in the Health Industry, National O.O. Bohomolets Medical University, Kiev, Ukraine; dDepartment of Clinical Science and Education, Karolinska Institutet, South Hospital, Stockholm, Sweden; eCentre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden; and fAstrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden.

Submitted 22 December 2011; accepted 19 June 2012.

Supported by the Swedish Heart–Lung Foundation (20060620), the Konsul ThC Bergh Foundation, the Stockholm County Council, the Swedish Asthma and Allergy Association Research Foundation (2006031-K), the Swedish Foundation for Health Care Sciences and Allergy Research, the Swedish Environmental Protection Agency (V-155-09), Centre for Allergy Research at KI (VA2006-0023), the Swedish Research Council (K2011-70X-20513-05-5), the Swedish Research Council FORMAS (2010-701), and the Swedish Institute (01217/2007).

The authors report no conflict of interests.

Supplemental digital content is available through direct URL citations in the HTML and PDF versions of this article ( This content is not peer-reviewed or copy-edited; it is the sole responsibility of the author.

Correspondence: Olena Gruzieva, Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13 Box 210, SE-171 77, Stockholm, Sweden. E-mail:

© 2013 Lippincott Williams & Wilkins, Inc.