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Home Outdoor NO2 and New Onset of Self-Reported Asthma in Adults

Jacquemin, Bénédictea,b; Sunyer, Jordia,c,d,e; Forsberg, Bertilf; Aguilera, Inmaculadaa,c,d; Briggs, Davidg; García-Esteban, Raquela,c,d; Götschi, Thomash; Heinrich, Joachimi; Järvholm, Bengtf; Jarvis, Debbiej; Vienneau, Danielleg; Künzli, Ninoa,c,d,k

doi: 10.1097/EDE.0b013e3181886e76
Air Pollution: Original Article

Background: Few studies have investigated new onset of asthma in adults in relation to air pollution. The aim of this study is to investigate the association between modeled background levels of traffic-related air pollution at the subjects’ home addresses and self-reported asthma incidence in a European adult population.

Methods: Adults from the European Respiratory Health Survey were included (n = 4185 from 17 cities). Subjects’ home addresses were geocoded and linked to outdoor nitrogen dioxide (NO2) estimates, as a marker of local traffic-related pollution. We obtained this information from the 1-km background NO2 surface modeled in APMoSPHERE (Air Pollution Modelling for Support to Policy on Health and Environmental Risk in Europe). Asthma incidence was defined as reporting asthma in the follow-up (1999 to 2001) but not in the baseline (1991 to 1993).

Results: A positive association was found between NO2 and asthma incidence (odds ratio 1.43; 95% confidence interval = 1.02 to 2.01) per 10 μg/m3. Results were homogeneous among centers (P value for heterogeneity = 0.59).

Conclusions: We found an association between a marker of traffic-related air pollution and asthma incidence in European adults.

Supplemental Digital Content is Available in the Text.

From the aCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; bINSERM, U780, Epidemiology and Biostatistics, Villejuif, France; cMunicipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain; dDepartment of Health and Experimental Sciences, University Pompeu Fabra, Barcelona, Spain; eCIBER in Epidemiology and Public Health (CIBERESP), Barcelona, Spain; fOccupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; gEpidemiology and Public Health, Imperial College, London, United Kingdom; hDepartment of Preventive Medicine, University of Southern California, Los Angeles, United States; iInstitute of Epidemiology, Helmholtz Zentrum München, Munich, Germany; jNational Heart and Lung Institute, Imperial College, London, United Kingdom; and kCatalan Institution for Research and Advanced Studies, ICREA, Barcelona, Spain.

Submitted 9 July 2007; accepted 14 April 2008; posted 14 October 2008.

Supported by European Commission, European Union, and additional local funders.

The APMoSPHERE study (EVK2-2002-00577) was a multi-centre project, funded under the EU Fifth Framework Programme as part of the Global Monitoring for Environment and Security (GMES) initiative. It was led by David Briggs (Imperial College London). Co-principal investigators were Asbjorn Aaheim (Centre for International Climate and Environmental Research, Oslo), Gerard Hoek (Utrecht University), Mike Petrakis (National Observatory of Athens), and Gavin Shaddick (University of Bath).

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Correspondence: Bénédicte Jacquemin, INSERM U780, Epidémiologie et Biostatistique, 16, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France. E-mail:

Home outdoor NO2 and new onset of self-reported asthma in adults: Erratum

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© 2009 Lippincott Williams & Wilkins, Inc.