BRIEF REPORTS: PDF OnlyActive and Passive Smoking and the Occurrence of Natural MenopauseCooper, Glinda S.; Sandler, Dale P.; Bohlig, MichaelAuthor Information From the Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC; and CODA, Inc, Research Triangle Park, NC. Epidemiology: November 1999 - Volume 10 - Issue 6 - p 771-773 Free Abstract We examined smoking in relation to natural menopause in 543 women who prospectively recorded menstrual data from their s. Mean age at natural menopause was 0.8 years younger (95% CL = —1.5, —0.0) in 98 women who smoked at menopause compared with 362 never-smokers (RR 1.3, 95% CI = 1.0–1.7). We did not observe a decrease in age at natural menopause in former smokers, a dose-response among current smokers, or a lower age at menopause with passive smoke exposure at home. These results suggest that the effect of smoking on ovarian senescence is limited to active smoking during the menopausal transition. (Epidemiology 1999; 10:771–773) © 1999 Lippincott Williams & Wilkins, Inc.