ORIGINAL ARTICLES: PDF OnlySexual Behavior, Sexually Transmitted Diseases, and Risk of Cervical CancerStone, Katherine M.1; Zaidi, Akbar1; Rosero-Bixby, Luis2; Oberle, Mark W.3; Reynolds, Gladys1; Larsen, Sandra4; Nahmias, Andre J.5; Lee, Francis K.5; Schachter, Julius6; Guinan, Mary E.1 Author Information 1Division of Sexually Transmitted Disease/HIV Prevention, National Center for Prevention Services, Atlanta, GA 3Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA 4Division of Sexually Transmitted Diseases, Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC),Atlanta, GA 2Asociación Demográfica Costarricense, San José, Costa Rica 5Department of Pediatrics, Division of Pediatric Infectious Diseases, Epidemiology and Immunology, Emory University School of Medicine, Atlanta, GA 6Departments of Epidemiology and Laboratory Medicine, University of California, San Francisco, CA. Participants are listed in the Appendix. Epidemiology: July 1995 - Volume 6 - Issue 4 - p 409-414 Free Abstract To explore sexually transmitted diseases and sexual behavior as risk factors for cervical cancer, we analyzed data from a population-based case-control study of breast and cervical cancer in Costa Rica. Data from 415 cases of cervical carcinoma in situ, 149 cases of invasive cervical cancer, and 764 controls were included in the analysis. Multivariate analysis showed that lifetime number of sex partners, first intercourse before age 15 years, number of livebirths, herpes simplex virus type 2 sero-positivity, and serologic evidence of previous chlamydial infection were predictors of carcinoma in situ. Serologic evidence of previous syphilis was not associated with carcinoma in situ. Predictors for invasive cervical cancer included lifetime number of sex partners, first intercourse before age 15 years, number of livebirths, serologic evidence of previous syphilis, herpes simplex type 2 infection, and chlamydial infection. Cigarette smoking, socioeconomic status, self-reported history of sexually transmitted diseases, and douching were not associated with either carcinoma in situ or invasive cervical cancer. © Lippincott-Raven Publishers.