ORIGINAL ARTICLES: PDF OnlyPsychoactive Medications and Injurious Motor Vehicle Collisions Involving Older DriversLeveille, Suzanne G.1,2; Büchner, David M.3,4; Koepsell, Thomas D.1,3,5; McCloskey, Lon W.5; Wolf, Marsha E.1,5; Wagner, Edward H.2,3Author Information 1Departments of Epidemiology and Health Services, University of Washington 3Departments of Health Services, University of Washington 2Departments of Center for Health Studies, Group Health Cooperative of Puget Sound 4Departments of Health Services Research and Development Field Program, Seattle Veterans Administration Medical Center 5Departments of Harborview Injury Prevention and Research Center, Seattle, WA. Epidemiology: November 1994 - Volume 5 - Issue 6 - p 591-598 Free Abstract Older drivers have the second highest risk for motor vehicle collisions of any age group, after adolescents. Psychoactive medications may place older drivers at increased risk for injurious motor vehicle collisions. We conducted a population-based matched case-control study of older drivers who were involved in injurious crashes during 1987 and 1988. The 234 cases and 447 controls were members of a large Seattle-based health maintenance organization. Use of antidepressants and opioid analgesics by older drivers was associated with increased risk for injurious motor vehicle collisions. Compared with non-users, current users of cyclic antidepressants had an adjusted relative risk (RR) of 2.3 [95% confidence interval (CI) = 1.1–4.8]. Opioid analgesic use was also associated with an elevated crash risk (adjusted RR = 1.8; 95% CI = 1.0–3.4). We found no evidence of a doserelated effect with either class of drug. Current use of benzodiazepines or sedating antihistamines had little association with increased risk for injurious collisions. (Epidemiology 1994;5:591–598) © Lippincott-Raven Publishers.