ORIGINAL ARTICLES: PDF OnlyExposure to Butadiene and Lymphatic and Hematopoietic CancerCole, Philip; Delzell, Elizabeth; Acquavella, JohnAuthor Information From the Department of Epidemiology, School of Public Health, and the Epidemiology Program, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, and the Epidemiology Department, Monsanto Company, St. Louis, MO. Epidemiology: March 1993 - Volume 4 - Issue 2 - p 96-103 Free Abstract Several follow-up studies have assessed lymphatic and hematopoietic cancer (LHC) among workers with potential exposure to 1,3-butadiene. These investigations of the styrene-butadiene rubber and butadiene manufacturing industries include 17,448 subjects with an average of 22 years of follow-up. When the results of the studies are combined, the total number of observed leukemia deaths is 36, compared with 34.2 expected. The standardized mortality ratio is 1.05, with a 95% confidence interval of 0.74–1.46. These null data are compatible with, at most, a weak positive association of butadiene with leukemia. There is little evidence of an association with other forms of LHC among styrene-butadiene rubber workers (55 observed/50.1 expected deaths). Only one study has evaluated directly the relation between estimates of butadiene exposure and leukemia, and this investigation reports a positive association. The result, however, cannot be interpreted as causal, because there is no satisfactory explanation for the marked discrepancy between this case-control study and a null follow-up study based on the same subjects. Overall, the epidemiologic evidence does not provide persuasive evidence that butadiene exposure causes LHC. © Lippincott-Raven Publishers.