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Confidence Interval Estimation of Interaction

Hosmer David W.; Lemeshow, Stanley
Epidemiology: September 1992
Brief Reports: PDF Only

Relative excess risk due to interaction, the proportion of disease among those with both exposures that is attributable to their interaction, and the synergy index have been proposed as measures of interaction in epidemiologic studies. This paper presents the methodology for obtaining confidence interval estimates of these indices utilizing routinely available output from multiple logistic regression software. (Epidemiology 1992;3:452–456)

© Lippincott-Raven Publishers.