Brief Reports: PDF OnlyGender and Histologic Type Variations in Smoking-Related Risk of Lung CancerBrownson, Ross C.1; Chang, Jian C.2; Davis, James R.3Author Information 1From the Division of Chronic Disease Prevention and Health Promotion 2From the Missouri Cancer Registry 3From the Bureau of Smoking, Tobacco, and Cancer, Missouri Department of Health, Columbia, MO. Epidemiology: January 1992 - Volume 3 - Issue 1 - p 61-64 Free Abstract We conducted a registry-based case-control study to examine the relation between smoking and lung cancer by gender and histologic type. Our analyses were based on 14,596 cases and 36,438 age-matched controls. Relative risk associated with ever-smoking, and level of smoking was consistently higher in females than males for all lung cancers combined (eversmoking odds ratios: 12.7 for females and 9.1 for males) and for each histologic type except adenocarcinoma. Female-male differences in relative risk were larger in younger age groups. The largest estimates of the attributable fraction due to smoking were observed for small cell carcinoma (97% in females and 91% in males); conversely, the smallest value was noted for adenocarcinoma (86% in females). Although our study was unable to measure absolute risk, our findings, other recent studies, and contemporary female smoking patterns raise concerns that female smokers may assume a proportionally greater burden of lung cancer morbidity and mortality in the future. (Epidemiology 1992;3:61–64) © Lippincott-Raven Publishers.