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Abstracts of the 2019 Annual Conference of the International Society for Environmental Epidemiology, August 25-28 2019, Utrecht, the Netherlands

Short-term and long-term effect of air pollution and its susceptibility factors on glucose metabolism in Korean adults: KNHANES study

M, Hwang1

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Environmental Epidemiology: October 2019 - Volume 3 - Issue - p 171
doi: 10.1097/01.EE9.0000607672.80134.b8
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TPS 671: Cardiometabolic effects of long-term air pollution exposure, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM

Background: The role of air pollution in the pathogenesis of diabetes has been presented by recent studies. We have carried out an epidemiological study on glucose metabolism and air pollution by exploration of level of fasting blood glucose (FBG) and hemoglobin A1c (HbA1c) with changes in air quality, depending on the characteristics of susceptible group.

Methods: We conducted a cross-sectional analysis on 10,014 representative national sample of adults (4,267 males and 5,747 females) from Korea National Health and Nutrition Examination Survey after combining with the Korean Air Quality Forecasting System data. We performed the analysis using the generalized linear model stratified by sex, age, presence of diabetes and obesity. We assessed the change of FBG and HbA1c associated with exposure to short-term and long-term exposure to particulate matter (PM10), fine particulate matter (PM2.5) and nitrogen dioxides (NO2).

Results: There were 1,110 subjects of diabetes and 3,263 of obesity. Overall, the level of FBG elevated 7.83 mg/dL [95% confidence interval (CI): 2.80-12.87] per interquartile range (IQR) increment of NO2 at lag6 and HbA1c increased 0.57% (95% CI: 0.04-1.09) per IQR increment of PM10 at moving average 0 to 60 days. The change of FBG and HbA1c increased higher in diabetes and obese group, especially in 65 years or over in male. There was a strong association between the increase of diabetic-related factors and exposure to air pollution.

Conclusions: Our study adds scientific evidence that exposure to short-term and long-term exposure to air pollution is associated with biological factors related with diabetes. This suggests that the impact of air quality should be reflected in aspects of chronic disease management when establishing local health care policies.

Copyright © 2019 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of Environmental Epidemiology. All rights reserved.