OPS 45: Cardiometabolic effects of air pollution, Room 117, Floor 1, August 26, 2019, 10:30 AM - 12:00 PM
Background: Air pollution is a leading preventable risk factor for cardiovascular diseases. Previous studies mostly relied on outdoor concentrations at residence, which might not represent personal exposure.
Aim: To evaluate the association between the estimated long-term personal exposure to PM2.5 and black carbon (BC) and intermediate cardiovascular markers in peri-urban South India.
Methods: We analyzed the third wave of the APCAPCS cohort (2010-2012), which recruited participants from 28 villages. We used predicted personal exposure to PM2.5 and BC derived from 610 participant-days of 24h average gravimetric PM2.5 and BC measurements and predictors related to usual time-activity. Outcomes included carotid intima-media thickness (CIMT), carotid-femoral pulse wave velocity (cfPWV) and augmentation index (AIx). We fit linear mixed models, adjusting for potential confounders and accounting for the clustered structure of the data.
Results: Of the 3017 participants (mean age 38 years), 1453 (48%) were females. The average PM2.5 exposure was 51 µg/m3 (range 13-85) for males, and 61 µg/m3 (range 40-120) for females, while the average BC was 4 µg/m3 (range 3-7) for males and 8 µg/m3 (range 3-22) for females. A 1-ln (μg/m3) increase of PM2.5 was positively associated with CIMT (0.125 mm, 95% CI 0.067, 0.183), cfPWV (0.308 m/s, 95% CI 0.005, 0.611) and AIx (3.5%, 95% CI 1.0, 6.0) among males. Both PM2.5 and BC were positively associated with AIx among females (3.7%, 95% CI 1.4, 6.0, per 1-ln [μg/m3] PM2.5; 1.7%, 95% CI 0.5, 2.8, per 1-ln [μg/m3] BC). Results were robust to several sensitivity analyses, but the effect of PM2.5 on cfPWV for males was attenuated after adjusting for blood pressure.
Conclusions: We provide new evidence on the effect of personal exposure to particulate matter and cardiovascular risk at high exposures levels and in a setting where personal exposure is not correlated with outdoor concentration at residence.