Personal Exposure to Ultrafine Particles is Associated with Reduced Lung Function in Adolescents with Asthma : Environmental Epidemiology

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Abstracts of the 2019 Annual Conference of the International Society for Environmental Epidemiology, August 25-28 2019, Utrecht, the Netherlands

Personal Exposure to Ultrafine Particles is Associated with Reduced Lung Function in Adolescents with Asthma

P, Ryan1; C, Wolfe1; H, Zang1; B, Huang1

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Environmental Epidemiology 3():p 345, October 2019. | DOI: 10.1097/01.EE9.0000609800.78808.d5
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TPS 681: Short-term health effects of air pollutants 1, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM

Background: Few studies have examined personal exposure to ultrafine particles (UFP) and respiratory health in adolescents. Our objective was to characterize personal UFP exposure and examine their association with respiratory symptoms and lung function among adolescents with and without asthma.

Methods: Participants (ages 13-17 years) completed seven days of personal UFP sampling. On each day, personal UFP exposure was recorded at one second intervals for three hours using the PUFP C200, a wearable UFP monitor. Ecological momentary assessment was used to assess the frequency of respiratory symptoms and spirometry was performed by trained technicians at the completion of the seven day sampling period. The percent-predicted forced expiratory volume in 1 second (% FEV1), forced vital capacity (% FVC), ratio of FEV1/FVC, and forced expiratory flow between 25% and 75% of the FVC (% FEF25-75) were calculated for each participant based on their age, sex, race, and height. Linear and zero-inflated Poisson regression models were used to estimate the association between log-transformed weekly median UFP exposures, lung function, and frequency of respiratory symptoms adjusting for BMI.

Results: A total of 98 adolescents (35% with asthma) were included in this analysis. Median weekly UFP exposures ranged from 351 – 58,300 p/cm3 (IQR = 5,478 p/cm3). Personal exposure to UFPs was associated with decreased lung function among adolescents with asthma; for a 10-fold increase in median UFP exposure the %FEV1 was decreased 10% (95% CI: -21, 0%), %FEV1/FVC decreased 11% (95%CI: -19.0, -3.5%) and the %FEF25-75 decreased 31% (95%CI: -55.5, -7.6%). No significant associations were observed between UFP exposure and lung function in children without asthma nor was UFP exposure associated with the frequency of respiratory symptoms in either asthmatic or non-asthmatic adolescents.

Conclusions: Exposure to UFP is associated with reduced lung function, but not increased respiratory symptoms, in children with asthma.

Copyright © 2019 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of Environmental Epidemiology. All rights reserved.