TPS 684: Long-term health effects of air pollutants 1, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM
Background: Numerous studies indicated cardiorespiratory effects associated with particulate matters, while evidence for risk estimates on renal diseases is limited.
Objectives: We aimed to estimate the association between mortality from renal failure (RF) and long-term exposures to both respirable suspended particles (PM10) and fine suspended particles (PM2.5).
Methods: In this prospective study, the Chinese Elderly Health Service Cohort enrolled total 66,820 local aged people with over 65 from 1998 to 2001, and followed them up to December 31, 2010. Yearly mean exposures to both PM10 and PM2.5 for individuals were predicted based on satellite data. Cox regression models with attained age as underlying time scale were used to estimate mortality risks of the total RF within all participants and participants with CKD, associated particulate matters (PM10 and PM2.5).
Results: Total 61,447 participants with sufficient information were included in analyses. During an approximate 10-year follow-up, we ascertained 443 deaths of the RF excluding deaths in the first year. The estimated hazard ratios (HR) for RF mortality within all participants per interquartile range (IQR) increase of both PM10 (4.74 µg/m3) and PM2.5 (3.22 µg/m3) were 1.23 (95% confidence interval [CI]: 1.06 to 1.43). The HRs for RF deaths within participants with CKD were 1.43 (1.17 to 1.75) and 1.42 (1.16, 1.74), respectively. Mortality HRs for AKI was associated with PM10 by 2.11 (1.38 to 2.63) and PM2.5 by 2.01 (1.38 to 2.20).
Conclusions: Long-term exposures to PM10 and PM2.5 may increase the risk of RF mortality in Hong Kong elderly population.