TPS 743: Health effects in pregnancy, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM
Background/Aim: Triclosan and parabens are widely used in some personal care products and other consumer products. These chemicals are associated with poor birth outcomes and may impact thyroid hormone regulation and homeostasis. Relevant epidemiologic studies are limited and results are inconsistent. Therefore, we investigated the effects of prenatal exposure to triclosan and parabens on thyroid hormones during pregnancy and birth outcomes, including gestational age, birth weight, body length, head circumference and abdominal circumference.
Methods: We recruit more than 300 women during 3rd stage pregnancy between 2017 and 2019 in Korean pregnant women, called The Mother and Kids Environmental health (MAKE) Study. We measured triclosan (TCS) and parabens (Methyl-paraben (MeP), Ethyl-paraben (EtP), Propyl-paraben (PrP)) concentrations in maternal urine samples, also collected information on birth outcomes, socio-economic status, and consumption habits of consumer products. We analyzed the association between thyroid hormone levels and birth outcomes according to triclosan and parabens levels using multivariate linear regression.
Results: The adjusted geometric means for urinary concentrations of TCS, MeP, EtP, and PrP were 0.24, 13.96, 9.45, and 1.70 ng/mL, respectively. We found positive associations between TSH and birth length in high TCS exposure group (ß=0.496, p=0.04). Also, both birth weight and length were significantly increased with TSH in high EtP exposure (weight, ß=0.114, p=0.024, length, ß=0.659, p=0.008).
Conclusions: This study found associations between thyroid hormones during pregnancy and birth outcomes such as birth weight and birth length in high exposure group of TCS and parabens. Further study is required to more fully elaborate this relation between prenatal exposure to triclosan and parabens and thyroid hormones during pregnancy on birth outcomes.
Acknowledgements: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2017R1C1B2012172), Republic of Korea.