Effects of Prenatal Per- and Polyfluroalkyl Substances Exposure on Birth Outcomes and Its Potential Mechanism : Environmental Epidemiology

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Abstracts of the 2019 Annual Conference of the International Society for Environmental Epidemiology, August 25-28 2019, Utrecht, the Netherlands

Effects of Prenatal Per- and Polyfluroalkyl Substances Exposure on Birth Outcomes and Its Potential Mechanism

Y, Tian1,,2; Q, Yao1; Y, Gao1; R, Shi1; Y, Zhang1

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Environmental Epidemiology 3():p 395, October 2019. | DOI: 10.1097/01.EE9.0000610412.29907.14
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TPS 741: Adverse birth outcomes 2, Exhibition Hall, Ground floor, August 28, 2019, 3:00 PM - 4:30 PM

Background: The potential effects of prenatal per- and polyfluroalkyl substances (PFASs) exposure on adverse birth outcomes have been observed in animals. Yet the results have been inconclusive in humans and little is known about its potential mechanism.

Objectives: We investigated the potential effect of prenatal PFASs exposure on birth outcomes and its potential mechanism in relation to placental 11β-hydroxysteroiddehydrogenase 2 (11β-HSD2).

Methods: In total, 369 mother-infant pairs were recruited from a Chinese birth cohort. Birth outcomes including weight, length, head circumference and chest circumference were obtained from medical records. Maternal serum was collected for 10 PFASs measurement including PFOA, PFOS, PFNA, PFUA, PFOSA, and PFHpA etc. The Protein level of 11β-HSD2 was detected in 290 placentas. Multiple linear regression models analyzed the associations between maternal PFASs level and birth outcomes as well as 11β-HSD2.

Results: We observed a significant decrease in birth weight with a log-unit increase in PFHpA concentrations regardless of whether exposures were modeled as continuous (β=-185.08, 95%CI: -357.83 to -12.33) or categorical variables (4thquartile: β=-143.16, 95%CI: -267.76 to -18.56). Significantly lower birth weight was also observed for PFOSA in the 3rdquartile (β=-150.95, 95%CI: -275.97 to -25.92) and 4thquartile (β=-139.95, 95%CI: -265.22 to -14.69). Additionally, higher PFOA (β=-0.15, 95%CI: -0.27 to -0.03), PFNA (β=-0.27, 95%CI: -0.48 to -0.07), PFUA (β=-0.27, 95%CI: -0.49 to -0.05) exposure was associated with decreased 11β-HSD2 while 11β-HSD2 was not significantly associated with any of birth outcomes.

Conclusions: Our findings suggested the potential impact of prenatal PFASs exposure on birth weight and placental 11β-HSD2. No association for 11β-HSD2 was present for any of birth outcomes, suggesting that decrease in placental 11β-HSD2 levels induced by PFASs exposure may not play an important role in fetal growth. More studies on the potential mechanisms underlying the effect of prenatal PFASs exposure on birth outcomes are warranted.

Copyright © 2019 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of Environmental Epidemiology. All rights reserved.