Long-term exposure to NO2 and PM2.5 on renal function in type 2 diabetes : Environmental Epidemiology

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Abstracts of the 2019 Annual Conference of the International Society for Environmental Epidemiology, August 25-28 2019, Utrecht, the Netherlands

Long-term exposure to NO2 and PM2.5 on renal function in type 2 diabetes

W, Chin1; Y, Chang2; L, Huang3; C, Hsu3,,4,,5; Y, Guo6,,7

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Environmental Epidemiology 3():p 69, October 2019. | DOI: 10.1097/01.EE9.0000606424.31160.52
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PDS 67: Outdoor air pollution cardiometabolic effects, Exhibition Hall (PDS), Ground floor, August 27, 2019, 4:30 PM - 5:30 PM

Background: Chronic kidney disease is a common comorbidity in patients with type 2 diabetes. Previous studies found that exposures to air pollutants are relevant factors for chronic kidney disease. However, few studies examined the impact of long-term exposures to air pollutants on renal function in type 2 diabetes. Therefore, in this study we followed patients with type 2 diabetes and assessed the effect of long-term exposure to air pollutants on their renal function.


Between 2003 and 2005, we recruited 1,316 participants with type 2 diabetes and followed through to the end of 2012. Demographics data, medical history, and baseline biomarkers were inquired and corrected at the beginning of recruitment. The Taiwanese Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to derive the estimated glomerular filtration rate (eGFR) which was obtained from blood test between 2006 and 2012. Monthly averages of five criteria air pollutants –CO, NO2, O3, SO2 and PM2.5 – were retrieved from 72 air-quality-monitoring stations, and interpolated to all participants’ home addresses using the kriging method. The association between air pollutants and eGFR decrease was assessed using mixed-effect model with random intercepts for 36 clinics.

Results: Among the participants, 985 subjects were qualified for and included in the analysis.

The mean ages of subjects was 57.5 years old and mean follow-up years were 5.3. The prevalence rates of eGFR lower than 60 mL/min/1.73 m2 at baseline and last surveys were 5.8 % and 11.5%. The decreased eGFR was significantly associated with NO2 and PM2.5 exposure within follow-up period.

Conclusion: Our study suggested that long-term exposure to air pollutants (NO2 and particulate matter 2.5) was associated with reduced renal function among Type 2 diabetes patients in Taiwan.

Copyright © 2019 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of Environmental Epidemiology. All rights reserved.