Not all cases of vomiting in pregnancy should be treated with ondansetron as a first-line approach. Pregnant patients with vomiting should be managed differently to adjust for the potential teratogenic side effects of medications.
Start with safer, proven medications (pyridoxine and doxylamine), and keep moving down the list before reaching for ondansetron, which has unclear risks to the fetus. Second- and third-line agents include H1 and dopamine antagonists, respectively. (UpToDate. May 27, 2020; https://bit.ly/2AxsOwj.)
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Dr. Linis the founder, CEO, and editor-in-chief of Academic Life in Emergency Medicine (https://www.ALiEM.com) and a professor of emergency medicine at the University of California San Francisco with interests in health professions education and digital scholarship. Follow her on Instagram@MichelleLinMDand on Twitter@M_Lin.