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Prognostic implications of ERG, PTEN, and fatty acid synthase expression in localized prostate cancer

Fathi, Anana; Mostafa, Naglaa A.a; Hefzi, Nabilab; Mansour, Khaled A.b

Egyptian Journal of Pathology: July 2018 - Volume 38 - Issue 1 - p 162–168
doi: 10.1097/01.XEJ.0000542240.74355.f8
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Background Prostate cancer (PCa) is cancer that varies in its behavior. Identifying the expression of genes involved in the pathogenesis can help in predicting its prognosis.

Aim The aim was to study the expression of erythroblast transformation-specific-related gene (ERG), phosphatase and tensin homolog deleted on chromosome 10 (PTEN), and fatty acid synthase (FASN) in localized PCa and their prognostic value.

Patients and methods Immunohistochemical analyses of ERG, PTEN, and FASN on PCa specimens were performed to evaluate their expression and correlation to variable clinicopathologic parameters.

Results Overexpression of ERG and FASN as well as PTEN loss were significantly associated with high prostate-specific antigen level (P=0.010, 0.000, .000, respectively), Gleason score greater than 7 (P=0.000, 0.000, 0.004, respectively), advanced tumor stage (P=0.022, 0.002, 0.008, respectively), biochemical recurrence (P=0.000, 0.018, 0.005, respectively), and shorter recurrence-free survival (P=0.021, 0.000, 0.009, respectively). PTEN loss was significantly correlated with both high ERG and high FASN expression (P=0.017, 0.000, respectively) without any detectable association between ERG and FASN (P=0.773). PTEN loss was the independent predictor of biochemical recurrence in multivariate analysis (P=0.006).

Conclusion Evaluation of PTEN in biopsies of patients with localized PCa can predict high-risk patients of biochemical recurrence.

Departments of aPathology

bClinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Correspondence to Naglaa A. Mostafa, MD, Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt Tel: +20 109 602 6022; fax: +20 552 307 830; e-mail: naglaramda@yahoo.com

Received April 1, 2018

Accepted April 30, 2018

©2018Egyptian Journal of Pathology
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