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Immunohistochemical evaluation of glucose transporter protein-1 in relation to cell proliferation in some soft tissue sarcomas

Abdel-Aziz, Hesham R.a; Megahed, Ola A.a; Abdelhamid, Mohamed I.b; Toam, Mostafa M.c

Egyptian Journal of Pathology: July 2018 - Volume 38 - Issue 1 - p 45–51
doi: 10.1097/01.XEJ.0000534716.52780.7f
ORIGINAL ARTICLES
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Background Soft tissue sarcomas (STSs) are mesenchymal tumors that mostly arise from extremities, trunk, or head and neck region. Their prognosis depends mainly on local recurrence, distant spread, and histologic grading. Hypoxia is the main cause of radioresistance and chemoresistance and metastases. Glucose transporter protein-1 (GLUT)1 is upregulated in hypoxia and is related to poor prognosis in some STSs.

Objective This study aims at presentation of clinical, morphological, and immunohistochemical properties of STSs with special emphasis on GLUT1 and Ki-67 expressions.

Materials and methods Fifty paraffin-embedded tissue blocks of STSs were included in this study between the years 2011 and 2013 and subjected for histopathological & immunohistochemical studies using Glut-1 and Ki-67.

Results Our results revealed statistical difference in GLUT1 immunostaining between the different sizes of the studied cases (P=0.039) and histologic grades (P=0.04). Furthermore, a statistically significant relationship between Ki-67 expression and histologic grades (P<0.001) and tumor size (P=0.004) was found. Moreover, a significant association between GLUT1 extension score and Ki-67 immunostaining in the STSs (P=0.012) was found.

Conclusion We conclude that altering expression and localization of key molecules controlling cell survival and metabolism such as GLUT1 may render the cancer cells more sensitive to treatments such as glycolysis inhibitors. These therapeutic strategies can be used in the anticancer therapy of sarcoma.

Departments of aPathology

bGeneral Surgery

cClinical Oncology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Correspondence to Hesham R. Abdel-Aziz, MD, Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt Tel: +20 100 443 4420; fax: +20 055 230 7830; e-mail: Hesham.pathology22@gmail.com

Received September 15, 2017

Accepted October 30, 2017

©2018Egyptian Journal of Pathology
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