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The effect of N-acetylcysteine on the liver following aluminium chloride exposure in adult male albino rat: a histological and immunohistochemical study

Mohamed, Hala Z.E.

The Egyptian Journal of Histology: June 2016 - Volume 39 - Issue 2 - p 150–161
doi: 10.1097/01.EHX.0000482396.95447.18
Original Articles
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Background There is considerable interest in the role of N-acetylcysteine (NAC) in attenuating aluminium chloride-induced hepatic damage.

Aim This study was undertaken to evaluate the effect of NAC on the liver following aluminium chloride exposure.

Materials and methods Sixty adult male rats were divided into three groups: The first group was the control group; the second group was treated with aluminium chloride (50 mg/kg/day) orally for 21 days; and the third group was treated with aluminium chloride (50 mg/kg/ day)+NAC (50 mg/kg/day) orally for 21 days. Liver specimens were processed for light, electron and immunohistochemical studies.

Results In the aluminium chloride-treated group, light microscopic examination showed degenerative changes in hepatocytes. The hepatocytes had vacuolated cytoplasm and apparent dilatation of the portal vessels. An extensive amount of collagen fibres were noted in the periportal zone, as well as an intense immune reaction for caspase. The ultrastructural study showed hepatocytes with condensation of the nuclear chromatin. The cytoplasm of the hepatocytes contained damaged mitochondria with disrupted cristae. The aluminium chloride+NAC-treated group showed significant attenuation of the histological alteration of the aluminium chloride-induced liver injury.

Conclusion NAC attenuates the damaging effect of aluminium chloride in the liver.

Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt

Correspondence to Hala Z.E. Mohamed, Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt Tel: +20 106 312 6036; e-mail: hala.zeinabdin@yahoo.com

Received September 19, 2015

Accepted March 12, 2016

© 2016 The Egyptian Journal of Histology
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