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Clinical and Experimental Circulation

Cardiac troponin T release patterns after off-pump coronary bypass surgery

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Huyghe, N.; Bouchez, S.; Moerman, A.; Wouters, P.; De Hert, S.

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European Journal of Anaesthesiology (EJA): June 2013 - Volume 30 - Issue - p 58-58
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Background: Cardiac troponin T (cTnT) is used as a specific marker for myocardial ischaemia, although its value remains ill-defined in off-pump coronary surgery (OPCAB). The present retrospective observational study aimed to determine the release patterns of cTnT after OPCAB and relate these to electrocardiographic changes.

Methods: After ethical committee approval and informed consent, data from 131 OPCAB patients were retrieved from a database of which 57 patients were excluded for further analysis because of missing data. cTnT samples were measured preoperatively, at arrival at the intensive care unit (ICU), and 6, 12, 24 and 48 hours afterwards. 12-lead ECGs were recorded preoperatively, at arrival at ICU, 1, 2 and 5 days postoperatively. cTnT levels were analysed using one-way and two-way analysis of variance for repeated measurements as appropriate. Data are expressed as mean ± standard deviation. A p-value < 0.05 was accepted as statistically significant.

Results: Three different postoperative cTnT levels could be identified: group 1 (6/74) showed an important increase of cTnT > 1 from which 3/6 patients developed a new Q-wave infarction. In group 2 (20/74) cTnT levels remained below 0.2.

Table
Table:
[data are mean±SD]

In the remaining group (group 3; 0< cTnT< 1) three distinct patterns could be identified: pattern A (8/39) manifested as a gradual increase of cTnT levels during the first 48 hours, pattern B (9/39) as an early peak at arrival and pattern C (22/39) demonstrated a peak value between 6-12 hours postoperatively.

Table
Table:
[mean±SD; * = significantly different vs pattern A]

Interestingly, the incidence of electrocardiographic diagnosis of myocardial infarction was significantly higher in the groups showing a transient peaking pattern (pattern B and C) than in those who showed a progressive rise in postoperative troponins (pattern C) (12/31 vs 0/8; p = 0.0471).

Conclusion: Different magnitudes of cTnT release could be identified after OPCAB surgery. In the patients with moderate cTnT release between 0 and 1 three different release patterns could be identified: gradual increase over 48 hours, a peak at arrival and those peaking between 6 and 12 hours.

© 2013 European Society of Anaesthesiology