Background and Goals: Dexmedetomidine is a selective α2 adrenoreseptor agonist with centrally mediated sympatholytic sedative and analgesic effects (1). The aim of the study was to invastigate the hemodynamic, anaesthetic and recovery effects of dexmedetomidine used as single preanaesthetic dose.
Material and Methods: ASA I-II patients, aged 20-60 years, scheduled for elective abdominal surgery. Patients were randomly divided into two groups to receive 0.5 μg kg−1 dexmedetomidine as a bolus dose in group D (n = 20) or saline solution as a bolus dose in group C (n = 20) within 60 second. Ten minutes after dexmedetomidine administration anaesthesia was induced with sodium thiopental until loss of eyelash reflexes. Vecuronium 0.1 mg/kg was used. The scores of tracheal intubations and thiopental doses were noted. Anesthesia was maintained with 4-6% desflurane (4Lmin−1 50% N2O + O2) according to bispectral index monitor (BIS) range of 40-60. Mean arterial pressures (MAP), heart rates (HR), oxygen saturations (SpO2) were monitorized. Ejection fractions (EF), end-diastolic indexes (EDI), cardiac indexes (CI), stroke indexes (SI) were monitorized and recorded with noninvasive thoracic electrical bioimpedance for 10min. intervals. Postoperative Aldrete Recovery Score (ARS) was recorded. Analysis of varience (ANOVA) were used to evaluate the groups. A p value <0.05 was accepted statistically significant.
Results: The EDI's, CI's, SVI's and EF's were similar in group I and II. The HR at 10th min (p = 0.024) and MAP at 30th min (p = 0.026) were significantly different. Intubation scores, thiopental doses and BIS are shown as mean ± SD in the table.
Conclusions: In conclusion, a single dose dexmedetomidine given before induction of anaesthesia decreased thiopental requirements without serious hemodynamic adverse effects and provided better intubation condition. In addition there is no effect on recovery times compared with saline.
1 Br J Clin Pharm 2000;51:27-33.