Local and Regional Anaesthesia
Background and Goal of Study: Concomitant application of chemotherapy and hyperthermia significantly improves the results of cancer treatment. Real hyperthermia above 40 degree C is most effective. Extracorporeal circulation is used for heating and perfusion of the extremity with the chemotherapeutic agents.
Materials and Methods: 21 patients, aged from 26 to 72 years, ASA II, were treated with CHPCH for recurrent melanoma. The patients were divided into two groups. Group A consisted of 10 patients treated under general anaesthesia and group B included 11 patients operated under general anaesthesia combined with continuous epidural analgesia.
The time of heating of the extremity and the highest temperature achieved during the procedure were assessed. The results were verified statistically with the Student's t-test, with the significance level at p < 0.05.
Results and Discussions: In group A, mean time of heating was 92,7 min ± 41,3 min and the mean temperature achieved was 39,7 degree C ± 1,07. In group B, heating lasted 59 min ± 27 min on the average, and the mean temperature achieved was 40,5 degree C ± 0,97.
- The time of heating of the extremity and the extracorporeal perfusion phase were shorter in the patients under combined epidural and general anaesthesia.
- In both groups mean temperature was almost the same.
- Despite full dose of heparin was administered no local complications were noted.
1 J. van der Zee, et al., Eur J Cancer, 1997, 10, 1546-50
2 F. Di Filippo, et al., World J Surg, 1995, 18, 359-62