Introduction: The aim of our study was to document changes in serum lipids and glucose levels during propofol or midazolam infusions for cardiac surgery in hyperlipidaemic patients.
Method: After approval by the hospital ethics committee, 30 hyperlipidaemic patients undergoing elective coronary artery bypass graft surgery were randomly assigned into two groups. One group of 15 patients received a continuous propofol infusion and the other group of 15 patients received a midazolam infusion as hypnotic agent for induction and maintenance of anaesthesia. Serum total cholesterol, triglyceride, HDL, LDL, VLDL and glucose levels were measured at seven periods perioperatively and postoperatively until postoperative day 3. For statistical analysis of the results, analysis of variance for repeated measures and t test for coupled series were used. P < 0.05 was accepted as statistically significant.
Results: Serum lipid levels were found to be decreased in both groups but there was no significant difference between the two groups except HDL levels. The decrease in triglyceride levels in the midazolam group was lower than the propofol group but not statistically significant. Glucose levels were found to be elevated perioperatively and until the 3rd postoperative day but there was no significant difference between the two groups.
Discussion: We can say that a propofol infusion does not increase significantly the risk of hyperlipidaemia when used in cardiac surgery.
1 Inoue S, Takauchi Y, Kayamori Y, et al. Propofol as a continuous infusion during cardiopulmonary bypass does not affect changes in serum free fatty acids European J Anaesthesiol
2 Myles PS, Buckland MR, Morgan DJ, et al. Serum lipid and glucose concentrations with a propofol infusion for cardiac surgery. J Cardiothorac Vasc Anesth