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Aspects of Cardiothoracic Anaesthesia

Comparison of different forms of ondansetron for the prophylaxis of PONV in patients undergoing coronary surgery under fast track anaesthesia: 046

Yavorovskiy, A.; Trekova, N.; Zjulyaeva, T.; Pavlova, Z.; Bunatian, A.

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European Journal of Anaesthesiology: June 2004 - Volume 21 - Issue - p 19-20
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Introduction: Despite continuous advances in anaesthetic and surgical procedures, the incidence of postoperative nausea and vomiting (PONV) has not changed accordingly, and continues to be a cause of distress for patients and to delay early postoperative recovery.

The aim of the present study was to assess the efficacy of two forms of ondansetron (i.v. and suppository) for the prophylaxis of PONV in patients undergoing coronary surgery under fast track anaesthesia.

Method: Patients were divided into three equal groups. Before induction of anaesthesia patients of Gp I received a single i.v. dose of ondansetron 4 mg, patients of Gp II received a suppository of 16 mg at night before operation and patients of a control group received nothing. Anaesthesia was induced with propofol 1 mg/kg and maintained by a combination of high thoracic epidural (ropivacaine 2% 60 mg plus morphine 3 mg) and general anaesthesia (isoflurane 0.6 to 1% in oxygen). Orotracheal intubation was facilitated by vecuronium.

Results: The characteristics of the patient groups are shown in table 1 and the incidence of PONV in table 2.

Table 1
Table 1:
Patient characteristics (mean ± SD).
Table 2
Table 2:
The incidence of PONV in Gp I and Gp II.

Discussion: The results of this study demonstrate that both forms of ondansetron are effective for the prophylaxis of PONV in patients undergoing coronary surgery under fast track anaesthesia.

Reference:

1 Gan TJ, Collis R, Hetreed M. Double-blind comparison of ondansetron, droperidol and saline in the prevention of postoperative nausea and vomiting. Brit J Anaesth. 1994; 72: 544-547.
    © 2004 European Society of Anaesthesiology