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Abstracts: Third Meeting of the International Society for Medical Gases (ISMG); Heidelberg, Germany, 29 September-1 October 1999

Organ-specific distribution and retention of xenon

Froeba, G.1; Kotzerke, J.2; Pazhur, R. J.1; Baeder, S.1; Marx, T.1; Georgieff, M.1

Section Editor(s): Graf, B. M.; Weimann, J.

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European Journal of Anaesthesiology: 2000 - Volume 17 - Issue - p 2
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Introduction: The low blood/gas partition coefficient of xenon (0.14) leads to rapid induction and emergence from anaesthesia. An accumulation in fatty tissue is expected, because of a fat/gas coefficient of 1.3. Furthermore, a transfer to the bowel could occur. This study was designed to quantify the kinetics and accumulation of xenon in different tissues.

Methods: After approval by the Institutional Animal Care Committee, seven pigs were anaesthetized with pentobarbitone. After tracheal intubation and catheter placement, they were ventilated with a mixture of 70% xenon131 and the isotope xenon133 in oxygen for 4 h; this was followed by a washout phase of 2 h. Throughout, the animals lay under a gamma camera to determine the specific distribution and retention of xenon in the body, by means of the accumulation of xenon133. The whole-body uptake of xenon was also calculated from the xenon133 activity in the different tissues. Data are presented as mean ± SD.

Results: During 4 h of xenon anaesthesia, there was an accumulation of xenon in the fat tissue of 20.8 ± 3.3% and in the bowel of 28.8 ± 6.3%. The uptake of xenon during that time was 1.8 ± 0.4 L. The excretion half-life of the lung could be defined as 2.5 ± 0.4 min, the half-life of the fat tissue as 96.4 ± 21.3 min and that of the bowel as 125.2 ± 21.1 min.

Conclusions: The retention in fat tissue and bowel, in conjunction with the long half-life of these tissues, leads to a significant loss of xenon during longer-lasting xenon anaesthesia. Furthermore, xenon should be used carefully in patients with occlusion of the bowel.

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The publication of this supplement has been supported by the sponsors of the Third ISMG Meeting: Abbott, AGA, AstraZeneca, Dräger, Janssen, Medex Medical, Messer Austria, Ohmeda, Pharmacia & Upjohn, Scott Medical Products, Siemens

© 2000 European Society of Anaesthesiology