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Abstracts: Third Meeting of the International Society for Medical Gases (ISMG); Heidelberg, Germany, 29 September-1 October 1999

Desflurane requirement is lower in combination with xenon than with nitrous oxide

Hargasser, S.; Entholzner, E.; Hänel, F.; Rucha, C.; Ortner, V.; Hipp, R.; Kochs, E.

Section Editor(s): Graf, B. M.; Weimann, J.

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European Journal of Anaesthesiology: 2000 - Volume 17 - Issue - p 7-8

ABSTRACT NO: 014

Introduction: The requirement for fentanyl to maintain anaesthesia with xenon (Xe) is only a fifth of that with nitrous oxide (N2O) [1]. The study investigates the requirement for desflurane (Des) added to either Xe or N2O to maintain anaesthesia.

Methods: After IRB approval and written informed consent, 37 patients (ASA I, age 18-35 years) undergoing lower-limb elective orthopaedic surgery were included in the study and randomly assigned to three groups. After induction (propofol, 2.5 mg kg−1), the unpremedicated patients received either xenon (group 1-Xe 70%, n = 12; group 2-Xe 50%, n = 13) or N2O (group 3-N2O 70%, n = 12). During the preincision period, 1.0-1.3 MAC was maintained by additional Des administration. After skin incision, Des was titrated by 0.7% end-tidal Des steps to maintain heart rate and blood pressure within 20% of preinduction values. At the end of operation after the patients were breathing spontaneously, the inhalational agents (Tdis) were discontinued.

Results: See Table 1.

Table 1
Table 1:
Median (min-max); duration of anaesthesia (min); end-tidal Des at Tdis (vol.%)

Conclusions: Depending on the applied concentration, Xe needs less supplementation with Des compared with N2O. Xe is more potent than N2O when used in combination with Des to maintain anaesthesia during orthopaedic surgery [2].

References:

1 Lachmann B, Armbruster S, Schairer W et al. Lancet 1990; 335: 1413-1415.
2 Cullen SC, Eger EI 2nd, Cullen BF, Gregory P. Anesthesiology 1969; 31: 305-309.

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The publication of this supplement has been supported by the sponsors of the Third ISMG Meeting: Abbott, AGA, AstraZeneca, Dräger, Janssen, Medex Medical, Messer Austria, Ohmeda, Pharmacia & Upjohn, Scott Medical Products, Siemens

© 2000 European Society of Anaesthesiology