ABSTRACT NO: 009
Introduction: Short-term inhalation of xenon (Xe) concentrations greater than 40% increases cerebral blood flow (CBF) in a dose-dependent manner . The longterm effects of Xe inhalation on CBF have not been determined. Therefore, CBF was measured by autoradiography in rats after 45 min of Xe inhalation.
Methods: Eighteen male Sprague-Dawley rats were randomized to untreated controls and two groups of Xe inhalation (n=6). After recovery from surgery during isoflurane anaesthesia, conscious animals inhaled either 30% oxygen/70% N2, 30% oxygen/30% Xe/40% N2, or 30% oxygen/70% Xe.
Results: After 45 min of 30% Xe inhalation, CBF was unchanged compared with animals breathing 30% oxygen/70% N2. After the same time period of 70% Xe inhalation, mCBF increased by 19%. FIGURE
Conclusions: Long-term inhalation of low (30%) Xe concentrations does not affect CBF. In contrast, high (70%) Xe concentrations exert moderate cerebrovascular effects.
1 Junck L. J Cereb Blood Flow Metab
The publication of this supplement has been supported by the sponsors of the Third ISMG Meeting: Abbott, AGA, AstraZeneca, Dräger, Janssen, Medex Medical, Messer Austria, Ohmeda, Pharmacia & Upjohn, Scott Medical Products, Siemens