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Cerebral blood flow effects of long-term xenon inhalation in conscious rats

Frietsch, T.1; Bogdanski, R.2; Blobner, M.2; Werner, C.2; Kuschinsky, W.3; Waschke, K. F.1

Section Editor(s): Graf, B. M.; Weimann, J.

European Journal of Anaesthesiology: 2000 - Volume 17 - Issue - p 4-5
Abstracts: Third Meeting of the International Society for Medical Gases (ISMG); Heidelberg, Germany, 29 September-1 October 1999
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1Dept. of Anaesthesiology, Faculty of Clin. Med., Mannheim, University, Heidelberg, 2Technical University of Munich, and 3Dept. of Physiology, University of Heidelberg, Germany

ABSTRACT NO: 009

Introduction: Short-term inhalation of xenon (Xe) concentrations greater than 40% increases cerebral blood flow (CBF) in a dose-dependent manner [1]. The longterm effects of Xe inhalation on CBF have not been determined. Therefore, CBF was measured by autoradiography in rats after 45 min of Xe inhalation.

Methods: Eighteen male Sprague-Dawley rats were randomized to untreated controls and two groups of Xe inhalation (n=6). After recovery from surgery during isoflurane anaesthesia, conscious animals inhaled either 30% oxygen/70% N2, 30% oxygen/30% Xe/40% N2, or 30% oxygen/70% Xe.

Results: After 45 min of 30% Xe inhalation, CBF was unchanged compared with animals breathing 30% oxygen/70% N2. After the same time period of 70% Xe inhalation, mCBF increased by 19%. FIGURE

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Figure

Conclusions: Long-term inhalation of low (30%) Xe concentrations does not affect CBF. In contrast, high (70%) Xe concentrations exert moderate cerebrovascular effects.

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References:

1 Junck L. J Cereb Blood Flow Metab 1985; 5: 126.

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The publication of this supplement has been supported by the sponsors of the Third ISMG Meeting: Abbott, AGA, AstraZeneca, Dräger, Janssen, Medex Medical, Messer Austria, Ohmeda, Pharmacia & Upjohn, Scott Medical Products, Siemens

© 2000 European Society of Anaesthesiology