Secondary Logo

Journal Logo

European Society of Anaesthesiologists; 8th Annual Meeting with the Austrian International Congress; Vienna, Austria, 1-4 April 2000

Safe duration of apnoea in anaesthetized patients after maximal nitrogen washout: correlation with FRC

Ciufu, M.; Kwitonda, C.; Braeckman, M.; Boogaerts, J.

Author Information
European Journal of Anaesthesiology: 2000 - Volume 17 - Issue - p 25-26
  • Free

Abstract A-82

Background and goal of study: Preoxygenation results in denitrogenation of the functional residual capacity (FRC) of the lungs, leading to an increase in oxygen reserve and delayed onset to hypoxia during apnoea [1, 2]. The study focuses on the relationship between CRF and duration of apnoea after maximal nitrogen washout.

Materials and methods: Three groups of patients were included after Ethical Committee approval: 7 healthy, 9 chronic obstructive pulmonary disease (COPD), and 6 mild to moderate obese patients. Each subject underwent preoxygenation which consists of 3 min of tidal volume using an oxygen flow of 10 L min−1, followed by rapid sequence induction of general anaesthesia and manual ventilation. The end-points of preoxygenation were defined as FEO2 > 0.90; FEN2 inferior to 5% (RAM spectrometer). After endotracheal intubation, the patients were allowed to remain apnoeic until SPO2 reached 93%. Variables registered: demography, duration (min) of preoxygenation and of apnoea, FRC real/FRC theoretical (%). ANOVA.

Results and discussion: *P < 0.05 compared with healthy. TABLE


Conclusion: FRC should be assessed preoperatively if difficult endotracheal intubation is suspected, to inform on the duration of safe apnoea.


1 Archer GW. Br J Anaesth 1974; 46: 358-360.
2 Norris MC. Anesthesiology 1985; 62: 827-829.

Section Description

The abstracts published in this supplement have been typeset from camera-ready copies prepared by the authors. Every effort has been made to reproduce faithfully the abstracts as submitted. However, no responsibility is assumed by the organisers for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of methods, products, instructions or ideas contained in the material herein. Because of the rapid advances in medical sciences, we recommend that independent verification of diagnoses and drug doses should be made.

Patient safety, equipment, monitoring and computers

© 2000 European Society of Anaesthesiology