Extent of sevoflurane-associated prolongation
European Society of Anaesthesiologists; 8th Annual Meeting with the Austrian International Congress; Vienna, Austria, 1-4 April 2000
Department of Anesthesiology and Critical Care Medicine, The Leopold-Franzens-University of Innsbruck, Austria
Background and goal of study: The potentially lethal tachyarrythmia torsade de pointes results from conditions known as congenital and acquired long QT interval. Volatile anaesthetics do influence the duration of the QT interval. In this experiment, we examined the extent of sevoflurane's effects on the QT interval.
Materials and methods: 20 female patients due to elective gynaecological surgery were studied. Patients were randomly assigned into two groups. Group S (n = 10) was anaesthetized using solely sevoflurane for induction and maintainace (face mask, 2.5 vol% end-tidal, duration: 30 min) and another ten patients (group SP) received sevoflurane anaesthesia for 15 min followed by propofol-monoanaesthesia (6 mg kg−1 h−1) for 15 min. Fresh gas flow was set to 8 L min−1 using an oxygen-in-air at FIO2 of 0.3. ECG recordings were taken before anaesthesia, 15 min after induction (baseline) 5 and 15 min after baseline (Table). QTc interval was calculated using: QTc=QT/√R-R(s). Data were analysed using an ANOVA for repeated measures and the Newman-Keuls test.
Results and discussion: The critical value of 440 ms QTC is exceeded after 30 min of sevoflurane induction and anaesthesia.
Conclusion: QTc interval was significantly lengthened (P < 0.001) after 30 minutes when using sevoflurane monoanaesthesia.
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Epidemiology in anaesthesia and intensive care© 2000 European Society of Anaesthesiology