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Core and fingertip thermal effects of intravenous anaesthesia induction: comparative study of thiopental, propofol and etomidate

Olmos, A.; Glez-de-Zárate, J.; Olmos, B.; Ruiz, N.; Gonzalez, M.

European Journal of Anaesthesiology: 2000 - Volume 17 - Issue - p 16
European Society of Anaesthesiologists; 8th Annual Meeting with the Austrian International Congress; Vienna, Austria, 1-4 April 2000

Department of Anaesthesiology, University Hospital, c/Ramón y Cajal no 3, (47011) Valladolid, Spain

    Abstract A-53

    Background and goal of study: Hypothermia after anaesthesia induction results from internal redistribution of heat. The loss of the heat to the environment, after the cutaneous vasodilatation, can be a mechanism added to the internal redistribution of the body heat. The aim of the study was to compare fingertip-core temperature changes during the onset of i.v. general anaesthesia induction with thiopental, propofol and etomidate.

    Materials and methods: Following HEC approval, 60 consenting ASA-I adults undergoing peripheral procedures were randomized into three groups according to IV anaesthetic induction agent used: G-I (thiopental, n=20), G-II (Propofol, n=20) and G-III (Etomidate, n=20). Anaesthesia induction (AI) was performed with thiopental (5 mg kg−1), or propofol (3 mg kg−1) or etomidate (0.3 mg kg−1) in every group. All patients received fentanyl (2 μg kg−1) and vecuronium (0.1 mg kg−1). After endotracheal intubation (EI), anaesthesia was maintained with 60% nitrous oxide in oxygen, and fentanyl (100 μg) at 10th min. We measured skin temperatures before and after (5, 10, 15 and 20 min) Al, oesophagus temperatures were measured immediately EI. We used disposable thermocouple probes (Mallincrkodt). Statistical analysis was performed using repeated-measures ANOVA, Student's t-test and Dunnets' tests (*P<0.05). FIGURE



    Results and discussion: In G-I and G-II, core temperature decreased 0.3-0.4 (*)°C, while in G-III we didn't find significant variations. The fingertip temperatures increased 6-7 (*) °C in G-I and G-II, while in the G-III only increased after 10 min.

    Conclusion: With thiopental or propofol, we found an abrupt increase of fingertip-temperature and a decrease of core temperature. While with etomidate the heating of the skin was late and moderate, the core-temperature stayed without significant variations.

    Section Description

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