Ultrasound-guided erector spinae plane block for postoperative analgesia in laparoscopic liver resection: A prospective, randomised controlled, patient and observer-blinded study : European Journal of Anaesthesiology | EJA

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Ultrasound-guided erector spinae plane block for postoperative analgesia in laparoscopic liver resection

A prospective, randomised controlled, patient and observer-blinded study

Kim, Doyeon; Kim, Jong Man; Choi, Gyu-Seong; Heo, Gunyoung; Kim, Gaab Soo; Jeong, Ji Seon

Author Information
European Journal of Anaesthesiology 38():p S106-S112, August 2021. | DOI: 10.1097/EJA.0000000000001475

Abstract

BACKGROUND 

Erector spinae plane block (ESPB) has been reported to manage postoperative pain effectively after various types of surgery. However, there has been a lack of study on the effect of ESPB after liver resection.

OBJECTIVES 

To investigate the analgesic effects of ESPB on pain control after laparoscopic liver resection compared with conventional pain management.

DESIGN 

Prospective, randomised controlled study.

SETTING 

A single tertiary care centre from February 2019 to February 2020.

PATIENTS 

A total of 70 patients scheduled to undergo laparoscopic liver resection.

INTERVENTIONS 

In the control group (n = 35), no procedure was performed. In the ESPB group (n = 35), ESPB was performed after induction of general anaesthesia. A total of 40 ml of ropivacaine 0.5% was injected at the T9 level bilaterally. After surgery, intravenous fentanyl patient-controlled analgesia was initiated. Fentanyl and hydromorphone were administered as rescue analgesics.

MAIN OUTCOME MEASURES 

The primary outcome was the cumulative postoperative opioid consumption at 24 h (morphine equivalent). The secondary outcomes were rescue opioid (fentanyl) dose in the postanaesthesia care unit (PACU) and pain severity at 1, 6, 12, 24, 48 and 72 h, assessed using a numerical rating scale (NRS) score.

RESULTS 

The median [IQR] postoperative opioid consumption during 24 hours following surgery was 48.2 [17.1] mg in the control group and 45.5 [35.8] mg in the ESPB group (median difference, 4.2 mg; 95% CI, −4.2 to 13.3 mg; P = 0.259). Conversely, rescue opioid in PACU was 5.3 [5.0] mg in the control group and 3.0 [1.5] mg in the ESPB group (median difference, 2.5 mg; 95% CI, 1.0 to 5.0 mg; P < 0.001). There was no significant difference in NRS scores point between the groups at any time.

CONCLUSION 

ESPB does not provide analgesic effect within 24 h after laparoscopic liver resection.

TRIAL REGISTRATION 

Clinical Trial Registry of Korea (https://cris.nih.go.kr.), identifier: KCT0003549)

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