Background and Aim of the Study:
Pregabalin is a gabapentinoid which has been shown to possess analgesic and anxiolytic properties. We presumed that pregabalin premedication may reduce surgical anxiety and postoperative pain. Hence, the present study was aimed to assess the efficacy of a single dose of pregabalin on postoperative pain and preoperative anxiety in patients undergoing lumbar spine surgery.
Materials and Methods:
Sixty patients posted for elective lumbar laminectomy and discectomy were randomly assigned to one of the three groups; Group C: received placebo capsules, Group P1: received pregabalin 150 mg and Group P2: received Pregabalin 300 mg capsules 2 hrs prior to induction of anesthesia. The levels of anxiety and pain were assessed with respective 100 mm visual analog scale (VAS). Postoperative fentanyl consumption and the occurrence of side effects were recorded. All patients were observed for 8 hrs, postoperatively.
There was a significant reduction in preoperative anxiety in both pregabalin groups as compared to control group (P = 0.001). VAS score for pain (at rest and during movement) was significantly decreased at all time intervals in both P1 and P2 groups as compared to control (P < 0.05). Fentanyl consumption (μg) in the postoperative period was significantly reduced in P1 (213 ± 112.9) and P2 (190.8 ± 45.3) groups as compared to the control group (339.1 ± 88.0) (P = 0.001). The level of sedation was higher in P2 group in the first 4 hrs (P < 0.05). The occurrence of postoperative nausea and vomiting was significantly more in control group as compared to the pregabalin groups (P = 0.018). The incidence of dizziness and blurring of vision was significantly more in P2 group in comparison to other two groups.
Single preoperative dose of pregabalin 150 or 300 mg was effective in reducing preoperative anxiety, postoperative pain, and total fentanyl consumption in patients undergoing lumbar laminectomy and discectomy. However, the incidence of postoperative side effects like sedation, dizziness and visual blurring were more in patients who received pregabalin 300 mg.
© 2012 European Society of Anaesthesiology