Share this article on:

Model-based control of neuromuscular block using mivacurium: design and clinical verification

Schumacher, P. M.*; Stadler, K. S.; Wirz, R.*; Leibundgut, D.*; Pfister, C. A.*; Zbinden, A. M.*

European Journal of Anaesthesiology (EJA): August 2006 - Volume 23 - Issue 8 - p 691-699
doi: 10.1017/S0265021506000524
Original Article

Background: Short-acting agents for neuromuscular block (NMB) require frequent dosing adjustments for individual patient's needs. In this study, we verified a new closed-loop controller for mivacurium dosing in clinical trials.

Methods: Fifteen patients were studied. T1% measured with electromyography was used as input signal for the model-based controller. After induction of propofol/opiate anaesthesia, stabilization of baseline electromyography signal was awaited and a bolus of 0.3 mg kg−1 mivacurium was then administered to facilitate endotracheal intubation. Closed-loop infusion was started thereafter, targeting a neuromuscular block of 90%. Setpoint deviation, the number of manual interventions and surgeon's complaints were recorded. Drug use and its variability between and within patients were evaluated.

Results: Median time of closed-loop control for the 11 patients included in the data processing was 135 [89–336] min (median [range]). Four patients had to be excluded because of sensor problems. Mean absolute deviation from setpoint was 1.8 ± 0.9 T1%. Neither manual interventions nor complaints from the surgeons were recorded. Mean necessary mivacurium infusion rate was 7.0 ± 2.2 μg kg−1 min−1. Intrapatient variability of mean infusion rates over 30-min interval showed high differences up to a factor of 1.8 between highest and lowest requirement in the same patient.

Conclusions: Neuromuscular block can precisely be controlled with mivacurium using our model-based controller. The amount of mivacurium needed to maintain T1% at defined constant levels differed largely between and within patients. Closed-loop control seems therefore advantageous to automatically maintain neuromuscular block at constant levels.

* University Hospital, Department of Anesthesiology, Bern

Swiss Federal Institute of Technology (ETH), Automatic Control Laboratory, Zurich

Correspondence to: Peter M. Schumacher, Department of Anesthesiology, University Hospital, CH-3010 Bern. E-mail:; Tel: +41 31 632 2767; Fax: +41 31 632 8848

Accepted for publication 8 February 2006

First published online 4 April 2006

© 2006 European Society of Anaesthesiology