Serum aflatoxin B1M1 and hepatocellular carcinoma in post-hepatitis C virus-infected Egyptian patients : Egyptian Liver Journal

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Serum aflatoxin B1M1 and hepatocellular carcinoma in post-hepatitis C virus-infected Egyptian patients

El-Folly, Runia F.a; El-Hadidi, Eman S.b; El-Sahar, Medhat H.c; El-Fouly, Nevien F.d; El-Hariri, Hazeme; Anwar, Ranac

Author Information

aTropical Medicine Department

bClinical Pathology Department, Faculty of Medicine, Ain Shams University

cHepatology and Gastroenterology Department, Police Hospitals

dTropical Medicine in Health Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority

eCommunity Medicine Department, National Research Centre, Cairo, Egypt

Correspondence to Nevien F. El-Fouly, MD, Department of Health Research, National Center for Radiation Research and Technology, Atomic Energy Authority, 3 Ahmed El Zomor St Nasr City, PO Box 9621, Cairo 11787, Egypt Tel: +20 22 287 665/ +20 100 163 6872; fax: +20 222 878 662; e-mail: [email protected]

Received May 27, 2018

Accepted October 31, 2018

Egyptian Liver Journal 8(3):p 82-85, July 2018. | DOI: 10.1097/01.ELX.0000528001.78130.1c

Abstract

Objectives 

Hepatitis C virus (HCV) chronically infected patients occur in about 3% of the world population with an increased risk to developing liver cirrhosis and cancer. Aflatoxin B1 (AFB1), a known human carcinogen, has a synergistic effect on HCV-induced hepatocellular carcinoma (HCC). We aimed to evaluate the association between AF B1M1 serum level and HCC in post-HCV-infected Egyptian patients.

Patients and methods 

Group I: 25 HCV-infected patients with HCC; group II: 25 HCV-infected patients without HCC, as well as control group of 25 healthy individuals.

Results 

Serum levels of α fetoprotein (AFP) and AFM1 were highly significant in group I than in group II and the control group (P<0.01). There was a significant positive correlation between the serum level of AFP and AFM1 in the studied groups (P<0.01). Concerning the correlation between serum AFM1 level and different quantitative variables, there was a significant positive correlation between serum AFM1 level and quantitative HCV-RNA values (level of viremia) (P<0.05). There was also a significant positive correlation between serum AFM1 level and size, number of HFL, and portal vein patency in group I. AFM1 serum level had less diagnostic performance in differentiating HCC from the HCV group than AFP.

Conclusion 

AFM1 serum level had a diagnostic performance in differentiating HCC from non-HCC cases but with less sensitivity and specificity value than AFP.

© 2018 Egyptian Liver Journal

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