Department of Anesthesiology, Shigasato Hospital, Otsu, Shiga, Japan

Department of Psychiatry, Shigasato Hospital, Otsu, Shiga, Japan

Department of Psychiatry, Shiga University of Medical Science, Otsu, Shiga, Japan

Department of Anesthesiology, Mitsubishi Kyoto Hospital, Nishikyoku Kyoto, Japan [email protected]

Department of Anesthesiology, Mitsubishi Kyoto Hospital, Nishikyoku Kyoto, Japan

Department of Psychiatry, Shiga University of Medical Science, Otsu, Shiga, Japan

Department of Psychiatry, Shigasato Hospital, Otsu, Shiga, Japan

Department of Psychiatry, Shigasato Hospital, Otsu, Shiga, Japan

Department of Psychiatry, Shiga University of Medical Science, Otsu, Shiga, Japan

Department of Psychiatry, Shigasato Hospital, Otsu, Shiga, Japan

H.K. received grants from Merck Sharp & Dohme LLC/MSD KK, Eisai Co, Ltd, and the SECOM Science and Technology Foundation. H.K. reports consulting fees from Takeda Pharmaceutical Co Ltd. H.K. was associated with a laboratory that was supported by donations from Fukuda Lifetech Co, Ltd and Fukuda Life Tech Keiji Co, Ltd to the Shiga University of Medical Science. The other authors declare no conflict of interest. The funders had no role in the study design; collection, analyses, or interpretation of data; writing of the manuscript; or decision to publish the results.