Objectives Skin picking disorder
(SPD) falls into the category of “obsessive-compulsive disorder and related disorders” in the Diagnostic and Statistical Manual of Mental Disorders
(Fifth Edition). Repetitive transcranial magnetic stimulation
has been reported to be a promising therapy in obsessive-compulsive disorder–related disorders. The purpose of this study was to demonstrate the efficacy of rTMS treatment
in patients with SPD.
Fifteen patients with SPD were assigned to receive 3 weeks' treatment
with either active (n = 8) or sham rTMS targeting the pre–supplementary motor area. Patients were evaluated using the Beck Depression Inventory, Beck Anxiety Inventory, Skin Picking Impact Scale, and the Yale-Brown Obsessive Compulsive Scale Modified for Neurotic Excoriation. Response to treatment
was defined as a ≥35% decrease on Yale-Brown Obsessive Compulsive Scale modified for Neurotic Excoriation.
response was achieved in 62.5% of patients (5/8) in the active group and 33.3% of patients (2/6) in the sham group. However, there were no significant differences between the groups in terms of primary and secondary outcomes.
In this exploratory study, active rTMS could not be demonstrated to be superior over sham in treatment
of SPD. The results of this study indicate the need for further rTMS studies to be conducted with larger sample sizes and subtypes of SPD.