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Does Rocuronium-Sugammadex Reduce Myalgia and Headache After Electroconvulsive Therapy in Patients With Major Depression?

Saricicek, Vahap MD*; Sahin, Levent MD*; Bulbul, Feridun MD; Ucar, Sevgi MD*; Sahin, Mehrican MD

doi: 10.1097/YCT.0b013e3182972bd2
Original Studies

Background We aimed to compare the effects of succinylcholine and rocuronium-sugammadex on development of myalgia and headache after electroconvulsive therapy (ECT).

Methods Forty-five patients undergoing ECT were enrolled in the study. Anesthesia induction was provided with propofol 1 mg/kg intravenously (IV) + succinylcholine 1 mg/kg IV in group S (n = 24) and propofol 1 mg/kg IV + rocuronium 0.3 mg/kg IV in group R (n = 21). Sugammadex 4 mg/kg IV was administered to group R after the motor seizure. The first 3 ECT sessions were evaluated on the basis of time to onset of spontaneous respiration following the induction, time to eye-opening response to verbal stimuli, and visual analog scale (VAS) scores for myalgia and headache at hours 2, 6, 12, and 24 following the ECT for all patients.

Results The times to onset of spontaneous respiration and eye-opening response to verbal stimuli were significantly shorter in all the 3 sessions in group R compared with group S (P < 0.002). Myalgia VAS scores at hours 2, 6, and 12 and the headache VAS scores at hours 2 and 6 were significantly higher in group S versus group R (P < 0,015).

Conclusions We concluded that the rates of myalgia and headache after ECT were significantly lower in group R than in group S, and also the awakening time (spontaneous respiration and opening the eyes in response to verbal stimuli) was significantly shorter in group R compared with group S.

From the *Department of Anesthesiology and Reanimation, †Department of Psychiatry, Faculty of Medicine, University of Gaziantep, and ‡Department of Anesthesiology, Obstetrics & Gynecology Hospital, Gaziantep, Turkey.

Received for publication February 12, 2013; accepted April 2, 2013.

Reprints: Vahap Saricicek, MD, Department of Anesthesiology and Reanimation, Gaziantep University Medical Faculty, 27310 Sahinbey, Gaziantep, Turkey (e-mail:

Financial source was provided by Gaziantep University.

The authors have no conflicts of interest to report.

© 2014 by Lippincott Williams & Wilkins