Institutional members access full text with Ovid®

Share this article on:

Long-Term Follow-Up of Adolescents With Resistant Depression Treated With Repetitive Transcranial Magnetic Stimulation

Mayer, Gad MD*; Aviram, Shai Ba*; Walter, Garry MD, PhD, FRANZCP; Levkovitz, Yechiel MD*; Bloch, Yuval MD*

doi: 10.1097/YCT.0b013e318238f01a
Original Studies

Objective There is a paucity of information about repetitive transcranial magnetic stimulation (rTMS) as a treatment for adolescent depression, and there are no data about its long-term effectiveness and safety in this age group. The aim of this study was to evaluate symptoms of depression and cognitive functioning in young people who had been treated 3 years previously with rTMS for resistant depression.

Methods Eight of 9 subjects who had participated in an open-label rTMS study were reassessed using the Child and Adolescent Depression Rating Scale—Revised and the Beck Depression Inventory II. Six of the subjects were also cognitively reassessed using the Cambridge Neuropsychological Test Automated Battery. The follow-up assessments were compared with the earlier pretreatment, inter-treatment and posttreatment assessments.

Results At 3-year follow-up, there was no evidence of deterioration in symptoms of depression or cognitive functioning compared to the last assessment after rTMS.

Conclusion Preliminary evidence suggests that rTMS treatment of resistant depression in adolescents is not associated with long-term cognitive deterioration and that posttherapy clinical improvement can be maintained. It seems that some subjects may derive long-term benefit from the rTMS course.

From the *Shalvata Mental Health Center, Hod HaSharon, Israel and †University of Sydney, Sydney, NSW, Australia.

Received for publication April 18, 2011; accepted August 16, 2011.

Reprints: Gad Mayer, MD, Shalvata Mental Health Center, PO Box 94, Hod Hasharon, Israel (e-mail:

This project was partially supported by young investigator NARSAD grant 2007.

The authors do not have any conflicts of interest in the conduct and reporting of this research.

© 2012 Lippincott Williams & Wilkins, Inc.