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Catatonia Among Adolescents With Down Syndrome: A Review and 2 Case Reports

Jap, Shannon N. MD; Ghaziuddin, Neera MD, MRCPsych (UK)

doi: 10.1097/YCT.0b013e31821d37c6
Case Reports

Catatonia is a relatively common condition with an estimated prevalence of 0.6% to 17% among youth with psychiatric disorders. Certain patient groups, such as those with autism, may be at a particularly high risk for catatonia. Most of the youth with catatonia are males with a diagnosis of a bipolar disorder. We describe here 2 adolescent females, both with Down syndrome, who presented with catatonia not accompanied by significant affective or psychotic symptoms or with a general medical condition. Both patients had functioned well until the onset of catatonic symptoms. In the current classification system used in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, catatonia is described in association with schizophrenia, as a specifier of affective disorders or secondary to general medical conditions. The cases described here highlight the problem with this classification system when patients fail to meet any of the 3 diagnostic categories under which catatonia is currently described.

From the Division of Child and Adolescent Psychiatry, University of Michigan, Ann Arbor, MI.

Received for publication January 10, 2011; accepted March 16, 2011.

Reprints: Neera Ghaziuddin, MD, MRCPsych (UK), Rachel Upjohn Building, 4250 Plymouth Rd, University of Michigan, Ann Arbor, MI 48109 (e-mail:

Dr Jap was a Fellow in Child and Adolescent Psychiatry at the time this manuscript was written.

The authors have no conflicts of interest or financial disclosures to report.

© 2011 Lippincott Williams & Wilkins, Inc.