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Electroconvulsive Therapy for Catatonia in Neuropsychiatric Systemic Lupus Erythematosus

Fam, Johnson MBBS, MMed*; Lee, Tih Shih MD, PhD; Lee, Huei Yen MBBS, MMed*; Ng, Beng Yeong MBBS, MMed*

doi: 10.1097/YCT.0b013e3181c1881f
Case Reports

Neuropsychiatric systemic lupus erythematosus encompasses neurological syndromes of the central, peripheral, and autonomic nervous system and a variety of psychiatric syndromes. Neuropsychiatric systemic lupus erythematosus presenting as catatonia is uncommon, and treatment of this condition is not well defined. Here we describe a case of neuropsychiatric systemic lupus erythematosus with catatonia and our treatment approach focusing on electroconvulsive therapy in conjunction with cyclophosphamide. We also discuss the pathophysiological underpinnings of the condition and the basis for treatment.

From the *Department of Psychiatry, Singapore General Hospital and †Duke-NUS Graduate Medical School, Singapore, Singapore.

Received for publication June 25, 2009; accepted July 15, 2009.

Reprints: Johnson Fam, MBBS, MMed, Department of Psychiatry, Singapore General Hospital, Outram Road, Singapore 169608, Singapore (e-mail:

© 2010 Lippincott Williams & Wilkins, Inc.